Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models

Parkinson's disease (PD) is characterized by the progressive loss of select neuronal populations, but the prodeath genes mediating the neurodegenerative processes remain to be fully elucidated. Trib3 (tribbles pseudokinase 3) is a stress-induced gene with proapoptotic activity that was previous...

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Veröffentlicht in:	The Journal of neuroscience 2015-07, Vol.35 (30), p.10731-10749
Hauptverfasser:	Aimé, Pascaline, Sun, Xiaotian, Zareen, Neela, Rao, Apeksha, Berman, Zachary, Volpicelli-Daley, Laura, Bernd, Paulette, Crary, John F, Levy, Oren A, Greene, Lloyd A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Blotting, Western Cell Cycle Proteins - biosynthesis Cell Death - physiology Dopaminergic Neurons - metabolism Female Fluorescent Antibody Technique Humans Immunoprecipitation Male Mice Nerve Degeneration - metabolism Parkinson Disease - metabolism PC12 Cells Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - biosynthesis Rats Real-Time Polymerase Chain Reaction Repressor Proteins - biosynthesis Reverse Transcriptase Polymerase Chain Reaction Substantia Nigra - metabolism Transfection Ubiquitin-Protein Ligases - metabolism
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