A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Genetic studies with S. cerevisiae Polδ (pol3-L612M) and Polε (pol2-M644G) mutant alleles, each of which display a higher rate for the generation of a specific mismatch, have led to the conclusion that Polε is the primary leading strand replicase and that Polδ is restricted to replicating the laggin...

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Veröffentlicht in:	Molecular cell 2015-07, Vol.59 (2), p.163-175
Hauptverfasser:	Johnson, Robert E., Klassen, Roland, Prakash, Louise, Prakash, Satya
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Base Pair Mismatch DNA Polymerase II - genetics DNA Polymerase II - metabolism DNA Polymerase III - genetics DNA Polymerase III - metabolism DNA Replication DNA, Fungal - genetics DNA, Fungal - metabolism Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Genome, Fungal Mutagenesis, Site-Directed Mutation Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
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