Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients
BACKGROUND:Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting. METHODS:We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transp...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2015-06, Vol.34 (6), p.562-565 |
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| container_title | The Pediatric infectious disease journal |
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| creator | Srinivasan, Ashok Klepper, Corie Sunkara, Anusha Kang, Guolian Carr, Jeanne Gu, Zhengming Leung, Wing Hayden, Randall T |
| description | BACKGROUND:Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting.
METHODS:We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied.
RESULTS:The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio2.57; 95% confidence interval0.98–6.75) and male sex (P = 0.04; odds ratio2.67; 95% confidence interval1.02–6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively.
CONCLUSIONS:Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control. |
| doi_str_mv | 10.1097/INF.0000000000000678 |
| format | Article |
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METHODS:We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied.
RESULTS:The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio2.57; 95% confidence interval0.98–6.75) and male sex (P = 0.04; odds ratio2.67; 95% confidence interval1.02–6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively.
CONCLUSIONS:Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0000000000000678</identifier><identifier>PMID: 25742243</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adenoviridae - isolation & purification ; Adenoviridae Infections - virology ; Adolescent ; Blood - virology ; Child ; Child, Preschool ; Feces - virology ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Infant ; Male ; Mamastrovirus - isolation & purification ; Norovirus - isolation & purification ; Retrospective Studies ; Sapovirus - isolation & purification ; Viral Load ; Viremia - virology ; Young Adult</subject><ispartof>The Pediatric infectious disease journal, 2015-06, Vol.34 (6), p.562-565</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4578-5427768352c9f2ac83b1307a1bf574687f37903469768a185283b7aa35255c633</citedby><cites>FETCH-LOGICAL-c4578-5427768352c9f2ac83b1307a1bf574687f37903469768a185283b7aa35255c633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25742243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srinivasan, Ashok</creatorcontrib><creatorcontrib>Klepper, Corie</creatorcontrib><creatorcontrib>Sunkara, Anusha</creatorcontrib><creatorcontrib>Kang, Guolian</creatorcontrib><creatorcontrib>Carr, Jeanne</creatorcontrib><creatorcontrib>Gu, Zhengming</creatorcontrib><creatorcontrib>Leung, Wing</creatorcontrib><creatorcontrib>Hayden, Randall T</creatorcontrib><title>Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND:Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting.
METHODS:We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied.
RESULTS:The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio2.57; 95% confidence interval0.98–6.75) and male sex (P = 0.04; odds ratio2.67; 95% confidence interval1.02–6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively.
CONCLUSIONS:Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.</description><subject>Adenoviridae - isolation & purification</subject><subject>Adenoviridae Infections - virology</subject><subject>Adolescent</subject><subject>Blood - virology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Mamastrovirus - isolation & purification</subject><subject>Norovirus - isolation & purification</subject><subject>Retrospective Studies</subject><subject>Sapovirus - isolation & purification</subject><subject>Viral Load</subject><subject>Viremia - virology</subject><subject>Young Adult</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1PGzEQhq0KVFLaf1BVPvay1B_rj70goQhKpKhUhZ6tieNtDN711nZA_fd1FRoBB3wZWfPMO-_oRegjJSeUdOrL4tvFCXn6pNJv0IwKzhrSaXWAZkR3tOFS6iP0LufbyvCWkrfoiAnVMtbyGbpdDBPYgmOPz9ZujPc-QcDXJcaAlxHWOI77hhs8YD_i727toSRv8aUboMQpelfq77q4Ac9dCPgmwZinAGPBP5z1k3djye_RYQ8huw-P9Rj9vDi_mV82y6uvi_nZsrGtULoRLVNKai6Y7XoGVvMV5UQBXfXVtdSq56qrh8iuUkC1YJVQAHVACCs5P0anO91puxrc2tbd9SYzJT9A-mMiePO8M_qN-RXvTSuoahWpAp8fBVL8vXW5mMFnW--C0cVtNlRqyqSopira7lCbYs7J9fs1lJh_MZkak3kZUx379NTifuh_LhXQO-AhhuJSvgvbB5fMxkEom9e1_wIkG56s</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Srinivasan, Ashok</creator><creator>Klepper, Corie</creator><creator>Sunkara, Anusha</creator><creator>Kang, Guolian</creator><creator>Carr, Jeanne</creator><creator>Gu, Zhengming</creator><creator>Leung, Wing</creator><creator>Hayden, Randall T</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201506</creationdate><title>Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients</title><author>Srinivasan, Ashok ; Klepper, Corie ; Sunkara, Anusha ; Kang, Guolian ; Carr, Jeanne ; Gu, Zhengming ; Leung, Wing ; Hayden, Randall T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4578-5427768352c9f2ac83b1307a1bf574687f37903469768a185283b7aa35255c633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenoviridae - isolation & purification</topic><topic>Adenoviridae Infections - virology</topic><topic>Adolescent</topic><topic>Blood - virology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Mamastrovirus - isolation & purification</topic><topic>Norovirus - isolation & purification</topic><topic>Retrospective Studies</topic><topic>Sapovirus - isolation & purification</topic><topic>Viral Load</topic><topic>Viremia - virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srinivasan, Ashok</creatorcontrib><creatorcontrib>Klepper, Corie</creatorcontrib><creatorcontrib>Sunkara, Anusha</creatorcontrib><creatorcontrib>Kang, Guolian</creatorcontrib><creatorcontrib>Carr, Jeanne</creatorcontrib><creatorcontrib>Gu, Zhengming</creatorcontrib><creatorcontrib>Leung, Wing</creatorcontrib><creatorcontrib>Hayden, Randall T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srinivasan, Ashok</au><au>Klepper, Corie</au><au>Sunkara, Anusha</au><au>Kang, Guolian</au><au>Carr, Jeanne</au><au>Gu, Zhengming</au><au>Leung, Wing</au><au>Hayden, Randall T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2015-06</date><risdate>2015</risdate><volume>34</volume><issue>6</issue><spage>562</spage><epage>565</epage><pages>562-565</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><abstract>BACKGROUND:Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting.
METHODS:We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied.
RESULTS:The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio2.57; 95% confidence interval0.98–6.75) and male sex (P = 0.04; odds ratio2.67; 95% confidence interval1.02–6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively.
CONCLUSIONS:Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25742243</pmid><doi>10.1097/INF.0000000000000678</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenoviridae - isolation & purification Adenoviridae Infections - virology Adolescent Blood - virology Child Child, Preschool Feces - virology Female Hematopoietic Stem Cell Transplantation Humans Infant Male Mamastrovirus - isolation & purification Norovirus - isolation & purification Retrospective Studies Sapovirus - isolation & purification Viral Load Viremia - virology Young Adult |
| title | Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients |
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