Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders

Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesi...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12623-12623, Article 12623
Hauptverfasser:	Naitou, Kiyotada, Shiina, Takahiko, Kato, Kurumi, Nakamori, Hiroyuki, Sano, Yuuki, Shimizu, Yasutake
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/376 692/617/375/1824 Adrenergic alpha-1 Receptor Antagonists - pharmacology Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Anesthetics, Local - pharmacology Animals Brain stem Colon - drug effects Colon - innervation Colon - physiology Defecation Defecation - drug effects Defecation - physiology Gastric motility Gastrointestinal Motility - drug effects Gastrointestinal Motility - physiology Humanities and Social Sciences Hypogastric Plexus - physiopathology Hypogastric Plexus - surgery Inactivation Injections, Spinal Intestine Irritable bowel syndrome Kinetics Lumbosacral Region Male Motility multidisciplinary Nerves Neurons Norepinephrine Norepinephrine - administration & dosage Norepinephrine - pharmacology Pain Pain perception Parasympathetic nervous system Pelvis Prazosin - pharmacology Rats, Sprague-Dawley Rectum - drug effects Rectum - innervation Rectum - physiology Rodents Sacrum Science Spinal cord Spinal Cord - drug effects Spinal Cord - physiology Tetrodotoxin Tetrodotoxin - pharmacology
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