Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders
Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesi...
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| Veröffentlicht in: | Scientific reports 2015-07, Vol.5 (1), p.12623-12623, Article 12623 |
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| description | Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesis that the descending noradrenergic pathway from the brain stem moderates gut motility, we examined effects of intrathecal application of noradrenaline to the spinal defecation center on colorectal motility. Colorectal intraluminal pressure and expelled volume were recorded
in vivo
in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients. |
| doi_str_mv | 10.1038/srep12623 |
| format | Article |
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in vivo
in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep12623</identifier><identifier>PMID: 26218221</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/376 ; 692/617/375/1824 ; Adrenergic alpha-1 Receptor Antagonists - pharmacology ; Adrenergic alpha-Agonists - administration & dosage ; Adrenergic alpha-Agonists - pharmacology ; Anesthetics, Local - pharmacology ; Animals ; Brain stem ; Colon - drug effects ; Colon - innervation ; Colon - physiology ; Defecation ; Defecation - drug effects ; Defecation - physiology ; Gastric motility ; Gastrointestinal Motility - drug effects ; Gastrointestinal Motility - physiology ; Humanities and Social Sciences ; Hypogastric Plexus - physiopathology ; Hypogastric Plexus - surgery ; Inactivation ; Injections, Spinal ; Intestine ; Irritable bowel syndrome ; Kinetics ; Lumbosacral Region ; Male ; Motility ; multidisciplinary ; Nerves ; Neurons ; Norepinephrine ; Norepinephrine - administration & dosage ; Norepinephrine - pharmacology ; Pain ; Pain perception ; Parasympathetic nervous system ; Pelvis ; Prazosin - pharmacology ; Rats, Sprague-Dawley ; Rectum - drug effects ; Rectum - innervation ; Rectum - physiology ; Rodents ; Sacrum ; Science ; Spinal cord ; Spinal Cord - drug effects ; Spinal Cord - physiology ; Tetrodotoxin ; Tetrodotoxin - pharmacology</subject><ispartof>Scientific reports, 2015-07, Vol.5 (1), p.12623-12623, Article 12623</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Jul 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-c5bfa9071f1a9177a7cea61434b4ba482c303dfdc2e9fd59ce8b5bbc93f6154e3</citedby><cites>FETCH-LOGICAL-c504t-c5bfa9071f1a9177a7cea61434b4ba482c303dfdc2e9fd59ce8b5bbc93f6154e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517467/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517467/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27911,27912,41107,42176,51563,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26218221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naitou, Kiyotada</creatorcontrib><creatorcontrib>Shiina, Takahiko</creatorcontrib><creatorcontrib>Kato, Kurumi</creatorcontrib><creatorcontrib>Nakamori, Hiroyuki</creatorcontrib><creatorcontrib>Sano, Yuuki</creatorcontrib><creatorcontrib>Shimizu, Yasutake</creatorcontrib><title>Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesis that the descending noradrenergic pathway from the brain stem moderates gut motility, we examined effects of intrathecal application of noradrenaline to the spinal defecation center on colorectal motility. Colorectal intraluminal pressure and expelled volume were recorded
in vivo
in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients.</description><subject>631/443/376</subject><subject>692/617/375/1824</subject><subject>Adrenergic alpha-1 Receptor Antagonists - pharmacology</subject><subject>Adrenergic alpha-Agonists - administration & dosage</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Anesthetics, Local - pharmacology</subject><subject>Animals</subject><subject>Brain stem</subject><subject>Colon - drug effects</subject><subject>Colon - innervation</subject><subject>Colon - physiology</subject><subject>Defecation</subject><subject>Defecation - drug effects</subject><subject>Defecation - physiology</subject><subject>Gastric motility</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Motility - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naitou, Kiyotada</au><au>Shiina, Takahiko</au><au>Kato, Kurumi</au><au>Nakamori, Hiroyuki</au><au>Sano, Yuuki</au><au>Shimizu, Yasutake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-07-28</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>12623</spage><epage>12623</epage><pages>12623-12623</pages><artnum>12623</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the hypothesis that the descending noradrenergic pathway from the brain stem moderates gut motility, we examined effects of intrathecal application of noradrenaline to the spinal defecation center on colorectal motility. Colorectal intraluminal pressure and expelled volume were recorded
in vivo
in anesthetized rats. Intrathecal application of noradrenaline into the L6-S1 spinal cord, where the lumbosacral defecation center is located, caused propulsive contractions of the colorectum. Inactivation of spinal neurons by tetrodotoxin blocked the effect of noradrenaline. Pharmacological experiments showed that the effect of noradrenaline is mediated primarily by alpha-1 adrenoceptors. The enhancement of colorectal motility by intrathecal noradrenaline was abolished by severing of the pelvic nerves. Our results demonstrate that noradrenaline acting on sacral parasympathetic preganglionic neurons through alpha-1 adrenoceptors causes propulsive motility of the colorectum in rats. Considering that visceral pain activates the descending inhibitory pathways including noradrenergic neurons, our results provide a rational explanation of the concurrent appearance of chronic abdominal pain and colonic motility disorders in IBS patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26218221</pmid><doi>10.1038/srep12623</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/443/376 692/617/375/1824 Adrenergic alpha-1 Receptor Antagonists - pharmacology Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - pharmacology Anesthetics, Local - pharmacology Animals Brain stem Colon - drug effects Colon - innervation Colon - physiology Defecation Defecation - drug effects Defecation - physiology Gastric motility Gastrointestinal Motility - drug effects Gastrointestinal Motility - physiology Humanities and Social Sciences Hypogastric Plexus - physiopathology Hypogastric Plexus - surgery Inactivation Injections, Spinal Intestine Irritable bowel syndrome Kinetics Lumbosacral Region Male Motility multidisciplinary Nerves Neurons Norepinephrine Norepinephrine - administration & dosage Norepinephrine - pharmacology Pain Pain perception Parasympathetic nervous system Pelvis Prazosin - pharmacology Rats, Sprague-Dawley Rectum - drug effects Rectum - innervation Rectum - physiology Rodents Sacrum Science Spinal cord Spinal Cord - drug effects Spinal Cord - physiology Tetrodotoxin Tetrodotoxin - pharmacology |
| title | Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders |
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