Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication

Herpesviruses require a nuclear egress complex (NEC) for efficient transit of nucleocapsids from the nucleus to the cytoplasm. The NEC orchestrates multiple steps during herpesvirus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nuclear membrane. In the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-07, Vol.112 (29), p.9010-9015
Hauptverfasser:	Leigh, Kendra E, Mayuri Sharma, My Sam Mansueto, Andras Boeszoermenyi, David J. Filman, James M. Hogle, Gerhard Wagner, Donald M. Coen, Haribabu Arthanari
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals antiviral agents Binding Sites Biological Sciences Calorimetry Cell Nucleus - metabolism cytomegalovirus Cytoplasm Databases, Protein Drug Discovery drug resistance drug target Herpes viruses Herpesviridae - metabolism Herpesvirus Human betaherpesvirus 5 Human cytomegalovirus Human herpesvirus 5 Humans Magnetic Resonance Spectroscopy Membranes Mice Models, Molecular Molecular Sequence Data Murine cytomegalovirus Muromegalovirus Mutation - genetics NMR Nuclear Lamina - metabolism Nuclear magnetic resonance nucleocapsid pathogens Peptides - metabolism pharmacokinetics Protein Binding Protein Multimerization Protein Subunits - chemistry Protein Subunits - metabolism Proteins proteinâprotein interactions Sequence Homology, Amino Acid Solutions Structure-Activity Relationship Viral Proteins - chemistry Viral Proteins - metabolism Virus Replication
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