Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to you...
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| Veröffentlicht in: | Annals of neurology 2015-08, Vol.78 (2), p.317-322 |
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| container_title | Annals of neurology |
| container_volume | 78 |
| creator | Wang, Joshua L. Lim, Andrew S. Chiang, Wei-Yin Hsieh, Wan-Hsin Lo, Men-Tzung Schneider, Julie A. Buchman, Aron S. Bennett, David A. Hu, Kun Saper, Clifford B. |
| description | The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322 |
| doi_str_mv | 10.1002/ana.24432 |
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Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.24432</identifier><identifier>PMID: 25921596</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Actigraphy ; Aged ; Aged, 80 and over ; Alzheimer Disease - metabolism ; Alzheimer Disease - physiopathology ; Biological clocks ; Case-Control Studies ; Cell Count ; Circadian rhythm ; Circadian Rhythm - physiology ; Female ; Humans ; Male ; Middle Aged ; Motor Activity - physiology ; Neurons - cytology ; Neurons - metabolism ; Neurons - physiology ; Suprachiasmatic Nucleus - cytology ; Suprachiasmatic Nucleus - metabolism ; Suprachiasmatic Nucleus - physiopathology ; Vasoactive Intestinal Peptide - metabolism</subject><ispartof>Annals of neurology, 2015-08, Vol.78 (2), p.317-322</ispartof><rights>2015 American Neurological Association</rights><rights>2015 American Neurological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6242-24db6a2d4532aeb1c7409e009bd1c296117fc9baa731cff64496d647317b61893</citedby><cites>FETCH-LOGICAL-c6242-24db6a2d4532aeb1c7409e009bd1c296117fc9baa731cff64496d647317b61893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.24432$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.24432$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25921596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Joshua L.</creatorcontrib><creatorcontrib>Lim, Andrew S.</creatorcontrib><creatorcontrib>Chiang, Wei-Yin</creatorcontrib><creatorcontrib>Hsieh, Wan-Hsin</creatorcontrib><creatorcontrib>Lo, Men-Tzung</creatorcontrib><creatorcontrib>Schneider, Julie A.</creatorcontrib><creatorcontrib>Buchman, Aron S.</creatorcontrib><creatorcontrib>Bennett, David A.</creatorcontrib><creatorcontrib>Hu, Kun</creatorcontrib><creatorcontrib>Saper, Clifford B.</creatorcontrib><title>Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322</description><subject>Actigraphy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Biological clocks</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Suprachiasmatic Nucleus - cytology</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Suprachiasmatic Nucleus - physiopathology</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhwB9AlrjAIa2_E1-QVhVdUKuCaBFHa-I4xCVxFjsp7L_H221XgIQ4WZafeTwzL0LPKTmihLBjCHDEhODsAVpQyWlRMaEfogXhShSScnGAnqR0TQjRipLH6IBJzajUaoE-Xc7rCLbzkAaYvMXBzXEMOMxD7WLCEBocXZoKsJO_8dMGWx8tNB4Cjt1m6oaEfcBj37iIu3mAkJ6iRy30yT27Ow_R59O3VyfvivMPq_cny_PCKiZYwURTK2CNkJyBq6ktBdEut1g31LLcKC1bq2uAklPbtkoIrRol8q2sFa00P0Rvdt71XA-usS5MEXqzjn6AuDEjePPnS_Cd-TreGCGppIpmwas7QRy_z3lIM_hkXd9DcOOcDC2JJJVkvPw_qnSlZcVFldGXf6HX4xxD3sQttRVW279f7ygbx5Sia_d9U2K2oZocqrkNNbMvfh90T96nmIHjHfDD927zb5NZXizvlcWuwqfJ_dxXQPxmVMlLab5crMwZv_p4dnq5Mpz_Aix0uqU</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Wang, Joshua L.</creator><creator>Lim, Andrew S.</creator><creator>Chiang, Wei-Yin</creator><creator>Hsieh, Wan-Hsin</creator><creator>Lo, Men-Tzung</creator><creator>Schneider, Julie A.</creator><creator>Buchman, Aron S.</creator><creator>Bennett, David A.</creator><creator>Hu, Kun</creator><creator>Saper, Clifford B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201508</creationdate><title>Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans</title><author>Wang, Joshua L. ; Lim, Andrew S. ; Chiang, Wei-Yin ; Hsieh, Wan-Hsin ; Lo, Men-Tzung ; Schneider, Julie A. ; Buchman, Aron S. ; Bennett, David A. ; Hu, Kun ; Saper, Clifford B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6242-24db6a2d4532aeb1c7409e009bd1c296117fc9baa731cff64496d647317b61893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Actigraphy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Biological clocks</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Neurons - physiology</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Suprachiasmatic Nucleus - physiopathology</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Joshua L.</creatorcontrib><creatorcontrib>Lim, Andrew S.</creatorcontrib><creatorcontrib>Chiang, Wei-Yin</creatorcontrib><creatorcontrib>Hsieh, Wan-Hsin</creatorcontrib><creatorcontrib>Lo, Men-Tzung</creatorcontrib><creatorcontrib>Schneider, Julie A.</creatorcontrib><creatorcontrib>Buchman, Aron S.</creatorcontrib><creatorcontrib>Bennett, David A.</creatorcontrib><creatorcontrib>Hu, Kun</creatorcontrib><creatorcontrib>Saper, Clifford B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Joshua L.</au><au>Lim, Andrew S.</au><au>Chiang, Wei-Yin</au><au>Hsieh, Wan-Hsin</au><au>Lo, Men-Tzung</au><au>Schneider, Julie A.</au><au>Buchman, Aron S.</au><au>Bennett, David A.</au><au>Hu, Kun</au><au>Saper, Clifford B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2015-08</date><risdate>2015</risdate><volume>78</volume><issue>2</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25921596</pmid><doi>10.1002/ana.24432</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Actigraphy Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Biological clocks Case-Control Studies Cell Count Circadian rhythm Circadian Rhythm - physiology Female Humans Male Middle Aged Motor Activity - physiology Neurons - cytology Neurons - metabolism Neurons - physiology Suprachiasmatic Nucleus - cytology Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus - physiopathology Vasoactive Intestinal Peptide - metabolism |
| title | Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans |
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