Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome
Summary Background A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h. Aim To determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/o...
Gespeichert in:
| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2015-08, Vol.42 (4), p.418-427 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 427 |
|---|---|
| container_issue | 4 |
| container_start_page | 418 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 42 |
| creator | Chumpitazi, B. P. Cope, J. L. Hollister, E. B. Tsai, C. M. McMeans, A. R. Luna, R. A. Versalovic, J. Shulman, R. J. |
| description | Summary
Background
A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.
Aim
To determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.
Methods
In a double‐blind, crossover trial, children with Rome III IBS completed a 1‐week baseline period. They then were randomised to a low FODMAP diet or typical American childhood diet (TACD), followed by a 5‐day washout period before crossing over to the other diet. GI symptoms were assessed with abdominal pain frequency being the primary outcome. Baseline gut microbial composition (16S rRNA sequencing) and metabolic capacity (PICRUSt) were determined. Metagenomic biomarker discovery (LEfSe) compared Responders (≥50% decrease in abdominal pain frequency on low FODMAP diet only) vs. Nonresponders (no improvement during either intervention).
Results
Thirty‐three children completed the study. Less abdominal pain occurred during the low FODMAP diet vs. TACD [1.1 ± 0.2 (SEM) episodes/day vs. 1.7 ± 0.4, P |
| doi_str_mv | 10.1111/apt.13286 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4514898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1697209911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4856-e754a88440a0c2a0be5de2c2b3440350dde5d2a3472ae972a82fea0dffe43e373</originalsourceid><addsrcrecordid>eNp1Uc1u1DAQthCIbgsHXgD5CIe0_ks24YC0KhSQilpV7dma2JOuwRtvbS-rfZi-Ky4pLT3gw1gafz_j-Qh5w9khL-cI1vmQS9E2z8iMy6auBJPNczJjoukq0XK5R_ZT-sEYa-ZMvCR7ouFMMS5n5PYCRhtWLqGlxrvRGfA0Rwf-A73eZLpyJobehRXSuwrxJ8ZEISKFlIJxkAtx6_LykR0xrcOYkOZAgfqwpSdnn74vzql1mKkbqVk6byOOEy8vkboYXYbeF5OwRU_TbrSxeL4iLwbwCV_f3wfk6uTz5fHX6vTsy7fjxWllVFs3Fc5rBW2rFANmBLAea4vCiF6WlqyZtaUhQKq5AOxKacWAwOwwoJIo5_KAfJx015t-hdbgmCN4vY6u_HinAzj99GV0S30dfmlVc9V2bRF4dy8Qw80GU9ZlpQa9hxHDJmneFFvWdZwX6PsJWhabUsThwYYzfRenLnHqP3EW7Nt_53pA_s2vAI4mwNZ53P1fSS_OLyfJ3828rhE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1697209911</pqid></control><display><type>article</type><title>Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Chumpitazi, B. P. ; Cope, J. L. ; Hollister, E. B. ; Tsai, C. M. ; McMeans, A. R. ; Luna, R. A. ; Versalovic, J. ; Shulman, R. J.</creator><creatorcontrib>Chumpitazi, B. P. ; Cope, J. L. ; Hollister, E. B. ; Tsai, C. M. ; McMeans, A. R. ; Luna, R. A. ; Versalovic, J. ; Shulman, R. J.</creatorcontrib><description>Summary
Background
A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.
Aim
To determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.
Methods
In a double‐blind, crossover trial, children with Rome III IBS completed a 1‐week baseline period. They then were randomised to a low FODMAP diet or typical American childhood diet (TACD), followed by a 5‐day washout period before crossing over to the other diet. GI symptoms were assessed with abdominal pain frequency being the primary outcome. Baseline gut microbial composition (16S rRNA sequencing) and metabolic capacity (PICRUSt) were determined. Metagenomic biomarker discovery (LEfSe) compared Responders (≥50% decrease in abdominal pain frequency on low FODMAP diet only) vs. Nonresponders (no improvement during either intervention).
Results
Thirty‐three children completed the study. Less abdominal pain occurred during the low FODMAP diet vs. TACD [1.1 ± 0.2 (SEM) episodes/day vs. 1.7 ± 0.4, P < 0.05]. Compared to baseline (1.4 ± 0.2), children had fewer daily abdominal pain episodes during the low FODMAP diet (P < 0.01) but more episodes during the TACD (P < 0.01). Responders were enriched at baseline in taxa with known greater saccharolytic metabolic capacity (e.g. Bacteroides, Ruminococcaceae, Faecalibacterium prausnitzii) and three Kyoto Encyclopedia of Genes and Genomes orthologues, of which two relate to carbohydrate metabolism.
Conclusions
In childhood IBS, a low FODMAP diet decreases abdominal pain frequency. Gut microbiome biomarkers may be associated with low FODMAP diet efficacy.
ClinicalTrials.gov identifier: NCT01339117.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.13286</identifier><identifier>PMID: 26104013</identifier><language>eng</language><publisher>England</publisher><subject>Abdominal Pain - etiology ; Adolescent ; Biomarkers - metabolism ; Child ; Cross-Over Studies ; Disaccharides - administration & dosage ; Double-Blind Method ; Female ; Fermentation ; Gastrointestinal Microbiome ; Humans ; Irritable Bowel Syndrome - diet therapy ; Irritable Bowel Syndrome - microbiology ; Male ; Monosaccharides - administration & dosage ; Oligosaccharides - administration & dosage ; Polymers - administration & dosage ; RNA, Ribosomal, 16S</subject><ispartof>Alimentary pharmacology & therapeutics, 2015-08, Vol.42 (4), p.418-427</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4856-e754a88440a0c2a0be5de2c2b3440350dde5d2a3472ae972a82fea0dffe43e373</citedby><cites>FETCH-LOGICAL-c4856-e754a88440a0c2a0be5de2c2b3440350dde5d2a3472ae972a82fea0dffe43e373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.13286$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.13286$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26104013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chumpitazi, B. P.</creatorcontrib><creatorcontrib>Cope, J. L.</creatorcontrib><creatorcontrib>Hollister, E. B.</creatorcontrib><creatorcontrib>Tsai, C. M.</creatorcontrib><creatorcontrib>McMeans, A. R.</creatorcontrib><creatorcontrib>Luna, R. A.</creatorcontrib><creatorcontrib>Versalovic, J.</creatorcontrib><creatorcontrib>Shulman, R. J.</creatorcontrib><title>Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.
Aim
To determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.
Methods
In a double‐blind, crossover trial, children with Rome III IBS completed a 1‐week baseline period. They then were randomised to a low FODMAP diet or typical American childhood diet (TACD), followed by a 5‐day washout period before crossing over to the other diet. GI symptoms were assessed with abdominal pain frequency being the primary outcome. Baseline gut microbial composition (16S rRNA sequencing) and metabolic capacity (PICRUSt) were determined. Metagenomic biomarker discovery (LEfSe) compared Responders (≥50% decrease in abdominal pain frequency on low FODMAP diet only) vs. Nonresponders (no improvement during either intervention).
Results
Thirty‐three children completed the study. Less abdominal pain occurred during the low FODMAP diet vs. TACD [1.1 ± 0.2 (SEM) episodes/day vs. 1.7 ± 0.4, P < 0.05]. Compared to baseline (1.4 ± 0.2), children had fewer daily abdominal pain episodes during the low FODMAP diet (P < 0.01) but more episodes during the TACD (P < 0.01). Responders were enriched at baseline in taxa with known greater saccharolytic metabolic capacity (e.g. Bacteroides, Ruminococcaceae, Faecalibacterium prausnitzii) and three Kyoto Encyclopedia of Genes and Genomes orthologues, of which two relate to carbohydrate metabolism.
Conclusions
In childhood IBS, a low FODMAP diet decreases abdominal pain frequency. Gut microbiome biomarkers may be associated with low FODMAP diet efficacy.
ClinicalTrials.gov identifier: NCT01339117.</description><subject>Abdominal Pain - etiology</subject><subject>Adolescent</subject><subject>Biomarkers - metabolism</subject><subject>Child</subject><subject>Cross-Over Studies</subject><subject>Disaccharides - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fermentation</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Irritable Bowel Syndrome - diet therapy</subject><subject>Irritable Bowel Syndrome - microbiology</subject><subject>Male</subject><subject>Monosaccharides - administration & dosage</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Polymers - administration & dosage</subject><subject>RNA, Ribosomal, 16S</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1Uc1u1DAQthCIbgsHXgD5CIe0_ks24YC0KhSQilpV7dma2JOuwRtvbS-rfZi-Ky4pLT3gw1gafz_j-Qh5w9khL-cI1vmQS9E2z8iMy6auBJPNczJjoukq0XK5R_ZT-sEYa-ZMvCR7ouFMMS5n5PYCRhtWLqGlxrvRGfA0Rwf-A73eZLpyJobehRXSuwrxJ8ZEISKFlIJxkAtx6_LykR0xrcOYkOZAgfqwpSdnn74vzql1mKkbqVk6byOOEy8vkboYXYbeF5OwRU_TbrSxeL4iLwbwCV_f3wfk6uTz5fHX6vTsy7fjxWllVFs3Fc5rBW2rFANmBLAea4vCiF6WlqyZtaUhQKq5AOxKacWAwOwwoJIo5_KAfJx015t-hdbgmCN4vY6u_HinAzj99GV0S30dfmlVc9V2bRF4dy8Qw80GU9ZlpQa9hxHDJmneFFvWdZwX6PsJWhabUsThwYYzfRenLnHqP3EW7Nt_53pA_s2vAI4mwNZ53P1fSS_OLyfJ3828rhE</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Chumpitazi, B. P.</creator><creator>Cope, J. L.</creator><creator>Hollister, E. B.</creator><creator>Tsai, C. M.</creator><creator>McMeans, A. R.</creator><creator>Luna, R. A.</creator><creator>Versalovic, J.</creator><creator>Shulman, R. J.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201508</creationdate><title>Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome</title><author>Chumpitazi, B. P. ; Cope, J. L. ; Hollister, E. B. ; Tsai, C. M. ; McMeans, A. R. ; Luna, R. A. ; Versalovic, J. ; Shulman, R. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4856-e754a88440a0c2a0be5de2c2b3440350dde5d2a3472ae972a82fea0dffe43e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abdominal Pain - etiology</topic><topic>Adolescent</topic><topic>Biomarkers - metabolism</topic><topic>Child</topic><topic>Cross-Over Studies</topic><topic>Disaccharides - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fermentation</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Irritable Bowel Syndrome - diet therapy</topic><topic>Irritable Bowel Syndrome - microbiology</topic><topic>Male</topic><topic>Monosaccharides - administration & dosage</topic><topic>Oligosaccharides - administration & dosage</topic><topic>Polymers - administration & dosage</topic><topic>RNA, Ribosomal, 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chumpitazi, B. P.</creatorcontrib><creatorcontrib>Cope, J. L.</creatorcontrib><creatorcontrib>Hollister, E. B.</creatorcontrib><creatorcontrib>Tsai, C. M.</creatorcontrib><creatorcontrib>McMeans, A. R.</creatorcontrib><creatorcontrib>Luna, R. A.</creatorcontrib><creatorcontrib>Versalovic, J.</creatorcontrib><creatorcontrib>Shulman, R. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chumpitazi, B. P.</au><au>Cope, J. L.</au><au>Hollister, E. B.</au><au>Tsai, C. M.</au><au>McMeans, A. R.</au><au>Luna, R. A.</au><au>Versalovic, J.</au><au>Shulman, R. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2015-08</date><risdate>2015</risdate><volume>42</volume><issue>4</issue><spage>418</spage><epage>427</epage><pages>418-427</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
A low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.
Aim
To determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.
Methods
In a double‐blind, crossover trial, children with Rome III IBS completed a 1‐week baseline period. They then were randomised to a low FODMAP diet or typical American childhood diet (TACD), followed by a 5‐day washout period before crossing over to the other diet. GI symptoms were assessed with abdominal pain frequency being the primary outcome. Baseline gut microbial composition (16S rRNA sequencing) and metabolic capacity (PICRUSt) were determined. Metagenomic biomarker discovery (LEfSe) compared Responders (≥50% decrease in abdominal pain frequency on low FODMAP diet only) vs. Nonresponders (no improvement during either intervention).
Results
Thirty‐three children completed the study. Less abdominal pain occurred during the low FODMAP diet vs. TACD [1.1 ± 0.2 (SEM) episodes/day vs. 1.7 ± 0.4, P < 0.05]. Compared to baseline (1.4 ± 0.2), children had fewer daily abdominal pain episodes during the low FODMAP diet (P < 0.01) but more episodes during the TACD (P < 0.01). Responders were enriched at baseline in taxa with known greater saccharolytic metabolic capacity (e.g. Bacteroides, Ruminococcaceae, Faecalibacterium prausnitzii) and three Kyoto Encyclopedia of Genes and Genomes orthologues, of which two relate to carbohydrate metabolism.
Conclusions
In childhood IBS, a low FODMAP diet decreases abdominal pain frequency. Gut microbiome biomarkers may be associated with low FODMAP diet efficacy.
ClinicalTrials.gov identifier: NCT01339117.</abstract><cop>England</cop><pmid>26104013</pmid><doi>10.1111/apt.13286</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2015-08, Vol.42 (4), p.418-427 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4514898 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abdominal Pain - etiology Adolescent Biomarkers - metabolism Child Cross-Over Studies Disaccharides - administration & dosage Double-Blind Method Female Fermentation Gastrointestinal Microbiome Humans Irritable Bowel Syndrome - diet therapy Irritable Bowel Syndrome - microbiology Male Monosaccharides - administration & dosage Oligosaccharides - administration & dosage Polymers - administration & dosage RNA, Ribosomal, 16S |
| title | Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T02%3A59%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Randomised%20clinical%20trial:%20gut%20microbiome%20biomarkers%20are%20associated%20with%20clinical%20response%20to%20a%20low%20FODMAP%20diet%20in%20children%20with%20the%20irritable%20bowel%20syndrome&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=Chumpitazi,%20B.%20P.&rft.date=2015-08&rft.volume=42&rft.issue=4&rft.spage=418&rft.epage=427&rft.pages=418-427&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1111/apt.13286&rft_dat=%3Cproquest_pubme%3E1697209911%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1697209911&rft_id=info:pmid/26104013&rfr_iscdi=true |