Cross-protection against influenza virus infection by intranasal administration of nucleoprotein-based vaccine with compound 48/80 adjuvant

The nucleoprotein (NP) of influenza viruses is highly conserved and therefore has become one of the major targets of current universal influenza vaccine (UIV) studies. In this study, the recombinant nucleoprotein (NP) of the A/PR/8/34 (H1N1) influenza virus strain was expressed using an Escherichia...

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Veröffentlicht in:	Human vaccines & immunotherapeutics 2015-02, Vol.11 (2), p.397-406
Hauptverfasser:	Zheng, Mei, Liu, Fen, Shen, Yiqing, Wang, Shilei, Xu, Wenting, Fang, Fang, Sun, Bing, Xie, Zhenyuan, Chen, Ze
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Administration, Intranasal Animals compound 48/80 Cross Protection Disease Models, Animal Female influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H9N2 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology INFLUENZA/Research Paper Injections, Intraperitoneal intranasal immunization Mice, Inbred BALB C mucosal adjuvant nucleoprotein Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology p-Methoxy-N-methylphenethylamine - administration & dosage RNA-Binding Proteins - administration & dosage RNA-Binding Proteins - immunology Survival Analysis Vaccination - methods Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Viral Core Proteins - administration & dosage Viral Core Proteins - immunology
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