TBP-like protein (TLP) interferes with Taspase1-mediated processing of TFIIA and represses TATA box gene expression

TBP-TFIIA interaction is involved in the potentiation of TATA box-driven promoters. TFIIA activates transcription through stabilization of TATA box-bound TBP. The precursor of TFIIA is subjected to Taspase1-directed processing to generate α and β subunits. Although this processing has been assumed t...

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Veröffentlicht in:	Nucleic acids research 2015-07, Vol.43 (13), p.6285-6298
Hauptverfasser:	Suzuki, Hidefumi, Isogai, Momoko, Maeda, Ryo, Ura, Kiyoe, Tamura, Taka-Aki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Chromatin - metabolism Endopeptidases - metabolism Gene regulation, Chromatin and Epigenetics HeLa Cells Humans Repressor Proteins - metabolism TATA Box TATA Box Binding Protein-Like Proteins - metabolism TATA-Box Binding Protein - metabolism Transcription Factor TFIIA - metabolism Transcriptional Activation
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