CCR2 inhibition sequesters multiple subsets of leukocytes in the bone marrow

Chemokine receptor CCR2 mediates monocyte mobilization from the bone marrow (BM) and subsequent migration into target tissues. The degree to which CCR2 is differentially expressed in leukocyte subsets and the contribution of CCR2 to these leukocyte mobilization from the BM are poorly understood. Usi...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.11664-11664, Article 11664
Hauptverfasser:	Fujimura, Naoki, Xu, Baohui, Dalman, Jackson, Deng, Hongping, Aoyama, Kohji, Dalman, Ronald L
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 631/250/127/98/571 631/250/1620 631/250/98/571 64/60 692/420/256 Animals Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism CC chemokine receptors CCR2 protein Dendritic cells Gene Expression Regulation Heterogeneity Humanities and Social Sciences Inflammation Leukocyte migration Leukocytes (neutrophilic) Leukocytes - cytology Leukocytes - metabolism Lipopolysaccharides Lymphocytes B Lymphocytes T Macrophages Mice Mice, Transgenic Monocyte chemoattractant protein 1 Monocytes multidisciplinary Neutrophils Organometallic Compounds - pharmacology Peripheral blood Receptors, CCR2 - antagonists & inhibitors Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Rodents Science Spleen
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