Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits

Common circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs1...

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Veröffentlicht in:	Diabetes care 2015-08, Vol.38 (8), p.1456-1466
Hauptverfasser:	Dashti, Hassan S, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Garaulet, Marta, Gottlieb, Daniel J, Hruby, Adela, Jacques, Paul F, Kiefte-de Jong, Jessica C, Lamon-Fava, Stefania, Scheer, Frank A J L, Bartz, Traci M, Kovanen, Leena, Wojczynski, Mary K, Frazier-Wood, Alexis C, Ahluwalia, Tarunveer S, Perälä, Mia-Maria, Jonsson, Anna, Muka, Taulant, Kalafati, Ioanna P, Mikkilä, Vera, Ordovás, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles blood glucose Blood Glucose - metabolism body mass index carbohydrate intake Cardiovascular system Circadian rhythm Circadian Rhythm Signaling Peptides and Proteins - genetics Cohort Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diet therapy Diabetes Mellitus, Type 2 - genetics Diet, Fat-Restricted Epidemiology/Health Services Research Europe European Continental Ancestry Group - genetics Fasting - blood Female Gene-Environment Interaction Genes genetic variation genotype-environment interaction glycemic effect glycemic index high carbohydrate diet high density lipoprotein cholesterol Humans Insulin resistance Insulin Resistance - genetics low fat diet Male Metabolism Middle Aged Multicenter Studies as Topic noninsulin-dependent diabetes mellitus Observational Studies as Topic Phenotype Polymorphism, Single Nucleotide - genetics sleep Sleep - physiology waist circumference Waist Circumference - genetics Whites
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