Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats

Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl 2 (C 14 H 21 N 3 O 2 ) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investig...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12379, Article 12379
Hauptverfasser:	Hajrezaie, Maryam, Shams, Keivan, Moghadamtousi, Soheil Zorofchian, Karimian, Hamed, Hassandarvish, Pouya, Emtyazjoo, Mozhgan, Zahedifard, Maryam, Majid, Nazia Abdul, Ali, Hapipah Mohd, Abdulla, Mahmood Ameen
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 14/1 49/1 631/154/309/507 631/61 82/51 Aberrant Crypt Foci - chemically induced Aberrant Crypt Foci - pathology Aberrant Crypt Foci - prevention & control Animals Antineoplastic Agents - administration & dosage Apoptosis Azoxymethane Carcinogenesis - drug effects Catalase Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - chemically induced Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Cytotoxicity Dose-Response Relationship, Drug Female Humanities and Social Sciences Male Malondialdehyde multidisciplinary Oral administration Proliferating cell nuclear antigen Rats Rats, Sprague-Dawley Rodents Schiff Bases - administration & dosage Schiff Bases - chemical synthesis Science Superoxide dismutase Treatment Outcome
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