Structural insights for HIV-1 therapeutic strategies targeting Vif

•APOBEC binding residues of Vif form contiguous surface regions.•Vif utilizes at least two different interfaces to target APOBEC3 family members.•A potential Vif oligomerization site is revealed in the crystal structure. HIV-1 viral infectivity factor (Vif) is a viral accessory protein that is requi...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2014-09, Vol.39 (9), p.373-380
Hauptverfasser:	Salter, Jason D., Morales, Guillermo A., Smith, Harold C.
Format:	Artikel
Sprache:	eng
Schlagworte:	antiretroviral agents Antiviral Agents - therapeutic use APOBEC APOBEC-1 Deaminase apolipoprotein B core-binding factor β crystal structure cullin 5 Cytidine Deaminase - metabolism Drug Design Elongin B/C HIV infections HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - virology HIV-1 - metabolism Human immunodeficiency virus 1 Humans pathogenicity protein-protein interactions therapeutics ubiquitin-protein ligase vif Gene Products, Human Immunodeficiency Virus - chemistry vif Gene Products, Human Immunodeficiency Virus - metabolism viral infectivity factor
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