A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking
We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction ses...
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| Veröffentlicht in: | Nature communications 2015-07, Vol.6 (1), p.7675-7675, Article 7675 |
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| creator | Luo, Yi-xiao Xue, Yan-xue Liu, Jian-feng Shi, Hai-shui Jian, Min Han, Ying Zhu, Wei-li Bao, Yan-ping Wu, Ping Ding, Zeng-bo Shen, Hao-wei Shi, Jie Shaham, Yavin Lu, Lin |
| description | We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.
Cue-based therapies for treating drug addiction have proven to be only partially effective. Here the authors demonstrate a new memory retrieval based treatment protocol for drug addiction that results in long-lasting inhibition of drug seeking behavior in rodents. |
| doi_str_mv | 10.1038/ncomms8675 |
| format | Article |
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Cue-based therapies for treating drug addiction have proven to be only partially effective. Here the authors demonstrate a new memory retrieval based treatment protocol for drug addiction that results in long-lasting inhibition of drug seeking behavior in rodents.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms8675</identifier><identifier>PMID: 26169171</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 631/378/1689/5 ; 692/700/565 ; 82/51 ; Animals ; Basolateral Nuclear Complex - metabolism ; Behavior, Animal - physiology ; Central Nervous System Stimulants - administration & dosage ; Cocaine - administration & dosage ; Conditioning (Psychology) - physiology ; Cues ; Drug-Seeking Behavior - physiology ; Endocytosis - physiology ; Extinction, Psychological - physiology ; Humanities and Social Sciences ; Inhibition (Psychology) ; Male ; Mental Recall - physiology ; Methylphenidate - administration & dosage ; multidisciplinary ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA - metabolism ; Recurrence ; Science ; Science (multidisciplinary) ; Self Administration</subject><ispartof>Nature communications, 2015-07, Vol.6 (1), p.7675-7675, Article 7675</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Jul 2015</rights><rights>Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ba84086f6dab96b5b2549d10c87afddee73c809dadccadb019f36b802ad83a4b3</citedby><cites>FETCH-LOGICAL-c442t-ba84086f6dab96b5b2549d10c87afddee73c809dadccadb019f36b802ad83a4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510700/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510700/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26169171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yi-xiao</creatorcontrib><creatorcontrib>Xue, Yan-xue</creatorcontrib><creatorcontrib>Liu, Jian-feng</creatorcontrib><creatorcontrib>Shi, Hai-shui</creatorcontrib><creatorcontrib>Jian, Min</creatorcontrib><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Zhu, Wei-li</creatorcontrib><creatorcontrib>Bao, Yan-ping</creatorcontrib><creatorcontrib>Wu, Ping</creatorcontrib><creatorcontrib>Ding, Zeng-bo</creatorcontrib><creatorcontrib>Shen, Hao-wei</creatorcontrib><creatorcontrib>Shi, Jie</creatorcontrib><creatorcontrib>Shaham, Yavin</creatorcontrib><creatorcontrib>Lu, Lin</creatorcontrib><title>A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.
Cue-based therapies for treating drug addiction have proven to be only partially effective. Here the authors demonstrate a new memory retrieval based treatment protocol for drug addiction that results in long-lasting inhibition of drug seeking behavior in rodents.</description><subject>13/1</subject><subject>631/378/1689/5</subject><subject>692/700/565</subject><subject>82/51</subject><subject>Animals</subject><subject>Basolateral Nuclear Complex - metabolism</subject><subject>Behavior, Animal - physiology</subject><subject>Central Nervous System Stimulants - administration & dosage</subject><subject>Cocaine - administration & dosage</subject><subject>Conditioning (Psychology) - physiology</subject><subject>Cues</subject><subject>Drug-Seeking Behavior - physiology</subject><subject>Endocytosis - physiology</subject><subject>Extinction, Psychological - physiology</subject><subject>Humanities and Social Sciences</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Mental Recall - physiology</subject><subject>Methylphenidate - administration & dosage</subject><subject>multidisciplinary</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, AMPA - metabolism</subject><subject>Recurrence</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Self Administration</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkU9P3DAQxa0KVNCyl36AKhKXqlWonTiOfamEVm1BQuIAnC3_mSyGxN7ayQq-fQ0L26XMxSPPT8_P8xD6RPAJwTX_7k0YhsRZ23xAhxWmpCRtVe_t9AdontIdzlULwin9iA4qRpggLTlE16eFD2voi5vFVTHAEOJjEWGMDtaqL-FhdN6MLvhiFYMBO0UoxlA4f-u0GzPZq1V6vrJxWhYJ4N755RHa71SfYP5yztDNr5_Xi7Py4vL3-eL0ojSUVmOpFaeYs45ZpQXTja4aKizBhreqsxagrQ3HwiprjLIaE9HVTHNcKctrRXU9Qz82uqtJD2AN-DGqXq6iG1R8lEE5-Xbi3a1chrWkDcFt3scMfXkRiOHPBGmUg0sG-l55CFOSeUuM8bohLKPH_6F3YYo-f--JaoRoCRWZ-rqhTAwpRei2ZgiWT3nJf3ll-POu_S36mk4Gvm2AlEd-CXHnzfdyfwFq6qKE</recordid><startdate>20150714</startdate><enddate>20150714</enddate><creator>Luo, Yi-xiao</creator><creator>Xue, Yan-xue</creator><creator>Liu, Jian-feng</creator><creator>Shi, Hai-shui</creator><creator>Jian, Min</creator><creator>Han, Ying</creator><creator>Zhu, Wei-li</creator><creator>Bao, Yan-ping</creator><creator>Wu, Ping</creator><creator>Ding, Zeng-bo</creator><creator>Shen, Hao-wei</creator><creator>Shi, Jie</creator><creator>Shaham, Yavin</creator><creator>Lu, Lin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Pub. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yi-xiao</au><au>Xue, Yan-xue</au><au>Liu, Jian-feng</au><au>Shi, Hai-shui</au><au>Jian, Min</au><au>Han, Ying</au><au>Zhu, Wei-li</au><au>Bao, Yan-ping</au><au>Wu, Ping</au><au>Ding, Zeng-bo</au><au>Shen, Hao-wei</au><au>Shi, Jie</au><au>Shaham, Yavin</au><au>Lu, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2015-07-14</date><risdate>2015</risdate><volume>6</volume><issue>1</issue><spage>7675</spage><epage>7675</epage><pages>7675-7675</pages><artnum>7675</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in humans. Here we show that non-contingent cocaine or methylphenidate injections (UCS retrieval) 1 h before the extinction sessions decreases cocaine-priming-induced reinstatement, spontaneous recovery, and renewal of cocaine seeking in rats. Unlike the CS-based memory retrieval-extinction procedure, the UCS memory retrieval manipulation decreases renewal and reinstatement of cocaine seeking in the presence of cocaine cues that were not present during extinction training and also decreases cocaine seeking when the procedure commences after 28 days of abstinence. The inhibitory effect of the UCS retrieval manipulation on cocaine-priming-induced reinstatement is mediated by regulation of AMPA-receptor endocytosis in the basolateral amygdala. The UCS memory retrieval-extinction procedure has superior relapse prevention characteristics than the CS memory retrieval-extinction procedure and could be a promising method for decreasing relapse in human addicts.
Cue-based therapies for treating drug addiction have proven to be only partially effective. Here the authors demonstrate a new memory retrieval based treatment protocol for drug addiction that results in long-lasting inhibition of drug seeking behavior in rodents.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26169171</pmid><doi>10.1038/ncomms8675</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 631/378/1689/5 692/700/565 82/51 Animals Basolateral Nuclear Complex - metabolism Behavior, Animal - physiology Central Nervous System Stimulants - administration & dosage Cocaine - administration & dosage Conditioning (Psychology) - physiology Cues Drug-Seeking Behavior - physiology Endocytosis - physiology Extinction, Psychological - physiology Humanities and Social Sciences Inhibition (Psychology) Male Mental Recall - physiology Methylphenidate - administration & dosage multidisciplinary Rats Rats, Sprague-Dawley Receptors, AMPA - metabolism Recurrence Science Science (multidisciplinary) Self Administration |
| title | A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking |
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