A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma

Purpose Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor (HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in preclinical models. We evaluated the addition of VPA to standard radiation therapy (RT) plus temozolomide (TMZ) in patients with newly...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-08, Vol.92 (5), p.986-992
Hauptverfasser:	Krauze, Andra V., MD, Myrehaug, Sten D., MD, Chang, Michael G., MD, Holdford, Diane J, Smith, Sharon, Shih, Joanna, MD, Tofilon, Philip J., PhD, Fine, Howard A., MD, Camphausen, Kevin, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Alkylating - therapeutic use BLOOD BONE MARROW Bone Marrow - drug effects Bone Marrow - radiation effects Brain Neoplasms - blood Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - radiotherapy Chemoradiotherapy - methods Chemotherapy, Adjuvant COMPARATIVE EVALUATIONS Dacarbazine - adverse effects Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use DIAGNOSIS DISEASE INCIDENCE Disease Progression Disease-Free Survival Drug Administration Schedule Female Glioblastoma - blood Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - radiotherapy GLIOMAS Hematology, Oncology and Palliative Medicine Histone Deacetylase Inhibitors - adverse effects Histone Deacetylase Inhibitors - therapeutic use Humans Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis PATIENTS RADIATION DOSES Radiation Tolerance - drug effects Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - adverse effects Radiation-Sensitizing Agents - metabolism Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Time Factors TOXICITY Valproic Acid - administration & dosage Valproic Acid - adverse effects Valproic Acid - blood
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