Resistance strength training exercise in children with spinal muscular atrophy
ABSTRACT Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor func...
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| Veröffentlicht in: | Muscle & nerve 2015-10, Vol.52 (4), p.559-567 |
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| creator | Lewelt, Aga Krosschell, Kristin J. Stoddard, Gregory J. Weng, Cindy Xue, Mei Marcus, Robin L. Gappmaier, Eduard Viollet, Louis Johnson, Barbara A. White, Andrea T. Viazzo-Trussell, Donata Lopes, Philippe Lane, Robert H. Carey, John C. Swoboda, Kathryn J. |
| description | ABSTRACT
Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52: 559–567, 2015 |
| doi_str_mv | 10.1002/mus.24568 |
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Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52: 559–567, 2015</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.24568</identifier><identifier>PMID: 25597614</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Child ; Child, Preschool ; Female ; home-based exercise program ; Humans ; Male ; Motor Activity - physiology ; Muscle Strength ; Muscle, Skeletal - physiopathology ; Muscular Atrophy, Spinal - physiopathology ; Muscular Atrophy, Spinal - rehabilitation ; neuromuscular disorder ; progressive resistance training exercise ; Reflex - physiology ; Reproducibility of Results ; Resistance Training - methods ; spinal muscular atrophy ; strength training exercise ; Treatment Outcome</subject><ispartof>Muscle & nerve, 2015-10, Vol.52 (4), p.559-567</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4868-d702766304f5819a59602032ad510b4dcd29c36c50ee46c50230b86ab0c26a3</citedby><cites>FETCH-LOGICAL-c4868-d702766304f5819a59602032ad510b4dcd29c36c50ee46c50230b86ab0c26a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.24568$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.24568$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25597614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewelt, Aga</creatorcontrib><creatorcontrib>Krosschell, Kristin J.</creatorcontrib><creatorcontrib>Stoddard, Gregory J.</creatorcontrib><creatorcontrib>Weng, Cindy</creatorcontrib><creatorcontrib>Xue, Mei</creatorcontrib><creatorcontrib>Marcus, Robin L.</creatorcontrib><creatorcontrib>Gappmaier, Eduard</creatorcontrib><creatorcontrib>Viollet, Louis</creatorcontrib><creatorcontrib>Johnson, Barbara A.</creatorcontrib><creatorcontrib>White, Andrea T.</creatorcontrib><creatorcontrib>Viazzo-Trussell, Donata</creatorcontrib><creatorcontrib>Lopes, Philippe</creatorcontrib><creatorcontrib>Lane, Robert H.</creatorcontrib><creatorcontrib>Carey, John C.</creatorcontrib><creatorcontrib>Swoboda, Kathryn J.</creatorcontrib><title>Resistance strength training exercise in children with spinal muscular atrophy</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52: 559–567, 2015</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>home-based exercise program</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity - physiology</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy, Spinal - physiopathology</subject><subject>Muscular Atrophy, Spinal - rehabilitation</subject><subject>neuromuscular disorder</subject><subject>progressive resistance training exercise</subject><subject>Reflex - physiology</subject><subject>Reproducibility of Results</subject><subject>Resistance Training - methods</subject><subject>spinal muscular atrophy</subject><subject>strength training exercise</subject><subject>Treatment Outcome</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi1UREPhwB9AeyyHbcff9gWpCrQgQirRovZmOV4nMWy8wd6lzb_HJW0Eh0o9zWGeeWbsF6E3GI4wADleDfmIMC7UMzTCoGXNuFZ7aASYqVpQfb2PXub8AwCwEvIF2iecaykwG6HpN59D7m10vsp98nHRL6s-2RBDXFT-1icXsq9CrNwytE0BqptQkLwO0bZV2eyG1qbK9qlbLzev0PO5bbN_fV8P0MXpx8vxp3pyfvZ5fDKpHVNC1Y0EIoWgwOZcYW25FkCAEttwDDPWuIZoR4Xj4D27K4TCTAk7A0eEpQfo_da6HmYr3zgfy8WtWaewsmljOhvM_50YlmbR_TaMg1BaF8HhvSB1vwafe7MK2fm2tdF3QzZYUqKwZFI9AcWCcMaIKOi7LepSl3Py891FGMxdUKZ8l_kbVGHf_vuEHfmQTAGOt8BNaP3mcZP5-v3iQVlvJ0qe_nY3YdNPIySV3FxNz4z8Mv5wOZ0wc0r_AEB0rXM</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Lewelt, Aga</creator><creator>Krosschell, Kristin J.</creator><creator>Stoddard, Gregory J.</creator><creator>Weng, Cindy</creator><creator>Xue, Mei</creator><creator>Marcus, Robin L.</creator><creator>Gappmaier, Eduard</creator><creator>Viollet, Louis</creator><creator>Johnson, Barbara A.</creator><creator>White, Andrea T.</creator><creator>Viazzo-Trussell, Donata</creator><creator>Lopes, Philippe</creator><creator>Lane, Robert H.</creator><creator>Carey, John C.</creator><creator>Swoboda, Kathryn J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7TS</scope><scope>5PM</scope></search><sort><creationdate>201510</creationdate><title>Resistance strength training exercise in children with spinal muscular atrophy</title><author>Lewelt, Aga ; Krosschell, Kristin J. ; Stoddard, Gregory J. ; Weng, Cindy ; Xue, Mei ; Marcus, Robin L. ; Gappmaier, Eduard ; Viollet, Louis ; Johnson, Barbara A. ; White, Andrea T. ; Viazzo-Trussell, Donata ; Lopes, Philippe ; Lane, Robert H. ; Carey, John C. ; Swoboda, Kathryn J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4868-d702766304f5819a59602032ad510b4dcd29c36c50ee46c50230b86ab0c26a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>home-based exercise program</topic><topic>Humans</topic><topic>Male</topic><topic>Motor Activity - physiology</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy, Spinal - physiopathology</topic><topic>Muscular Atrophy, Spinal - rehabilitation</topic><topic>neuromuscular disorder</topic><topic>progressive resistance training exercise</topic><topic>Reflex - physiology</topic><topic>Reproducibility of Results</topic><topic>Resistance Training - methods</topic><topic>spinal muscular atrophy</topic><topic>strength training exercise</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewelt, Aga</creatorcontrib><creatorcontrib>Krosschell, Kristin J.</creatorcontrib><creatorcontrib>Stoddard, Gregory J.</creatorcontrib><creatorcontrib>Weng, Cindy</creatorcontrib><creatorcontrib>Xue, Mei</creatorcontrib><creatorcontrib>Marcus, Robin L.</creatorcontrib><creatorcontrib>Gappmaier, Eduard</creatorcontrib><creatorcontrib>Viollet, Louis</creatorcontrib><creatorcontrib>Johnson, Barbara A.</creatorcontrib><creatorcontrib>White, Andrea T.</creatorcontrib><creatorcontrib>Viazzo-Trussell, Donata</creatorcontrib><creatorcontrib>Lopes, Philippe</creatorcontrib><creatorcontrib>Lane, Robert H.</creatorcontrib><creatorcontrib>Carey, John C.</creatorcontrib><creatorcontrib>Swoboda, Kathryn J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewelt, Aga</au><au>Krosschell, Kristin J.</au><au>Stoddard, Gregory J.</au><au>Weng, Cindy</au><au>Xue, Mei</au><au>Marcus, Robin L.</au><au>Gappmaier, Eduard</au><au>Viollet, Louis</au><au>Johnson, Barbara A.</au><au>White, Andrea T.</au><au>Viazzo-Trussell, Donata</au><au>Lopes, Philippe</au><au>Lane, Robert H.</au><au>Carey, John C.</au><au>Swoboda, Kathryn J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance strength training exercise in children with spinal muscular atrophy</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2015-10</date><risdate>2015</risdate><volume>52</volume><issue>4</issue><spage>559</spage><epage>567</epage><pages>559-567</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods: We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results: Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions: A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52: 559–567, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25597614</pmid><doi>10.1002/mus.24568</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Child Child, Preschool Female home-based exercise program Humans Male Motor Activity - physiology Muscle Strength Muscle, Skeletal - physiopathology Muscular Atrophy, Spinal - physiopathology Muscular Atrophy, Spinal - rehabilitation neuromuscular disorder progressive resistance training exercise Reflex - physiology Reproducibility of Results Resistance Training - methods spinal muscular atrophy strength training exercise Treatment Outcome |
| title | Resistance strength training exercise in children with spinal muscular atrophy |
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