Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors

Staphylococcus aureus is well adapted to the human host. Evasion of the host phagocyte response is critical for successful infection. The staphylococcal bicomponent pore-forming toxins Panton-Valentine leukocidin LukSF-PV (PVL) and γ-hemolysin CB (HlgCB) target human phagocytes through interaction w...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-08, Vol.195 (3), p.1034-1043
Hauptverfasser:	Spaan, András N, Schiepers, Ariën, de Haas, Carla J C, van Hooijdonk, Davy D J J, Badiou, Cédric, Contamin, Hugues, Vandenesch, François, Lina, Gérard, Gerard, Norma P, Gerard, Craig, van Kessel, Kok P M, Henry, Thomas, van Strijp, Jos A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Proteins - immunology Bacterial Toxins - immunology Cattle Cell Line Exotoxins - immunology HEK293 Cells Hemolysin Proteins - immunology Humans Immune Evasion - immunology Leukocidins - immunology Mice Mice, Inbred C57BL Molecular Sequence Data Neutrophils - immunology Phagocytes - immunology Protein Binding Protein Structure, Tertiary Receptor, Anaphylatoxin C5a - antagonists & inhibitors Receptor, Anaphylatoxin C5a - immunology Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - immunology Staphylococcal Infections - immunology Staphylococcus aureus Staphylococcus aureus - pathogenicity
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