Pharmacological stimulation of hypoxia inducible factor-1α facilitates the corticosterone response to a mild acute stressor

•Interactions between HIF1α and the HPA axis may facilitate the stress response.•HIF stimulation via DMOG enhances the corticosterone response to mild stress.•HIF stimulation alters expression of glucocorticoid co-chaperones after stress.•FKBP4 and FKBP5 may mediate crosstalk between the HIF pathway...

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Veröffentlicht in:	Neuroscience letters 2015-07, Vol.600, p.75-79
Hauptverfasser:	Harrell, Constance S., Rowson, Sydney A., Neigh, Gretchen N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Airpuff startle Amino Acids, Dicarboxylic - pharmacology Animals Corticosterone - blood Dimethyloxalylglycine FKBP4 FKBP5 Hippocampus - metabolism Hypoxia inducible factor 1α Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Male Rats, Wistar Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Stress Stress, Psychological - metabolism Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism
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