AAV2/8-humanFOXP3 gene therapy shows robust anti-atherosclerosis efficacy in LDLR-KO mice on high cholesterol diet

Inflammation is a key etiologic component in atherogenesis. Previously we demonstrated that adeno-associated virus (AAV) 2/8 gene delivery of Netrin1 inhibited atherosclerosis in the low density lipoprotein receptor knockout mice on high-cholesterol diet (LDLR-KO/HCD). One important finding from thi...

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Veröffentlicht in:	Journal of translational medicine 2015-07, Vol.13 (1), p.235-235, Article 235
Hauptverfasser:	Cao, M, Theus, S A, Straub, K D, Figueroa, J A, Mirandola, L, Chiriva-Internati, M, Hermonat, P L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Aorta - diagnostic imaging Aorta - pathology Atherosclerosis Atherosclerosis - blood Atherosclerosis - physiopathology Atherosclerosis - therapy Cholesterol Cholesterol, Dietary - blood Dependovirus Diet Diet therapy Forkhead Transcription Factors - genetics Gene therapy Genes Genetic aspects Genetic Therapy - methods Genetic transcription Health aspects Humans Inflammation - pathology Male Mice Mice, Knockout Receptors, LDL - genetics T cells T-Lymphocytes, Regulatory Transgenes Ultrasonography
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