Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma

Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have been proposed as new therapeutic targets. We analyzed frequency and molecular features of FGFR-TACC fusions and explored the therapeutic...

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Veröffentlicht in:	Clinical cancer research 2015-07, Vol.21 (14), p.3307-3317
Hauptverfasser:	Di Stefano, Anna Luisa, Fucci, Alessandra, Frattini, Veronique, Labussiere, Marianne, Mokhtari, Karima, Zoppoli, Pietro, Marie, Yannick, Bruno, Aurelie, Boisselier, Blandine, Giry, Marine, Savatovsky, Julien, Touat, Mehdi, Belaid, Hayat, Kamoun, Aurelie, Idbaih, Ahmed, Houillier, Caroline, Luo, Feng R, Soria, Jean-Charles, Tabernero, Josep, Eoli, Marica, Paterra, Rosina, Yip, Stephen, Petrecca, Kevin, Chan, Jennifer A, Finocchiaro, Gaetano, Lasorella, Anna, Sanson, Marc, Iavarone, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - mortality Cancer DNA Mutational Analysis - methods Female Fluorescent Antibody Technique Glioma - drug therapy Glioma - genetics Glioma - mortality Humans Immunohistochemistry Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Life Sciences Male Mice Mice, Nude Microtubule-Associated Proteins - genetics Molecular Targeted Therapy Oncogene Proteins, Fusion - genetics Pyrazoles - therapeutic use Quinoxalines - therapeutic use Receptor, Fibroblast Growth Factor, Type 3 - genetics Reverse Transcriptase Polymerase Chain Reaction - methods Xenograft Model Antitumor Assays
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