Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

Recombinant hepatitis C virus (HCV) clones propagated in human hepatoma cell cultures yield relatively low infectivity titers. Here, we adapted the JFH1-based Core-NS2 recombinant SA13/JFH1C3405G,A3696G (termed SA13/JFH1orig), of the poorly characterized genotype 5a, to Huh7.5 cells, yielding a viru...

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Veröffentlicht in:	Journal of virology 2015-08, Vol.89 (15), p.7758-7775
Hauptverfasser:	Mathiesen, Christian K, Prentoe, Jannick, Meredith, Luke W, Jensen, Tanja B, Krarup, Henrik, McKeating, Jane A, Gottwein, Judith M, Bukh, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Genotype Hepacivirus - genetics Hepacivirus - physiology Hepatitis C - genetics Hepatitis C - metabolism Hepatitis C - virology Hepatitis C virus Humans Mutation Peptide Fragments - genetics Peptide Fragments - metabolism Recombination, Genetic Serial Passage Tetraspanin 28 - genetics Tetraspanin 28 - metabolism Viral Core Proteins - genetics Viral Core Proteins - metabolism Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Assembly Virus-Cell Interactions
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