PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer

Protein arginine methyl transferase 1 (PRMT1) was shown to be up-regulated in cancers and important for cancer cell proliferation. However, the role of PRMT1 in lung cancer progression and metastasis remains incompletely understood. In the present study, we show that PRMT1 is an important regulator...

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Veröffentlicht in:	The Journal of biological chemistry 2015-05, Vol.290 (21), p.13479-13489
Hauptverfasser:	Avasarala, Sreedevi, Van Scoyk, Michelle, Karuppusamy Rathinam, Manoj Kumar, Zerayesus, Sereke, Zhao, Xiangmin, Zhang, Wei, Pergande, Melissa R., Borgia, Jeffrey A., DeGregori, James, Port, J. David, Winn, Robert A., Bikkavilli, Rama Kamesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arginine - genetics Blotting, Western cadherin-1 (CDH1) (epithelial cadherin) (E-cadherin) Cadherins - genetics Cadherins - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - secondary Cell Movement Cell Proliferation DNA Methylation Epithelial-Mesenchymal Transition epithelial-mesenchymal transition (EMT) Fluorescent Antibody Technique, Indirect Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology metastasis Mice Molecular Bases of Disease Molecular Sequence Data N-cadherin Neoplasm Invasiveness Nuclear Proteins - genetics Nuclear Proteins - metabolism Prmt1 protein methylation Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Real-Time Polymerase Chain Reaction Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Sequence Homology, Amino Acid Tumor Cells, Cultured Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism Twist1 Wound Healing Xenograft Model Antitumor Assays
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