Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...

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Veröffentlicht in:	The Journal of biological chemistry 2015-06, Vol.290 (23), p.14705-14716
Hauptverfasser:	Habets, Roger A.J., Groot, Arjan J., Yahyanejad, Sanaz, Tiyanont, Kittichoat, Blacklow, Stephen C., Vooijs, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Amino Acid Sequence Animals Calcium - metabolism Cell Biology Cell Line Humans Leukemia - genetics Leukemia - metabolism Mice Molecular Sequence Data Mutation Protein Unfolding Receptor, Notch1 - chemistry Receptor, Notch1 - metabolism Receptor, Notch2 - chemistry Receptor, Notch2 - genetics Receptor, Notch2 - metabolism
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