DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

Triggering receptor expressed on myeloid cells 2 (TREM2) is a DAP12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells. Previous studies have suggested that TREM2/DAP12 signaling pathway reduces inflammatory responses and promotes phagocytosis of apoptotic neuro...

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Veröffentlicht in:	The Journal of biological chemistry 2015-06, Vol.290 (25), p.15866-15877
Hauptverfasser:	Zhong, Li, Chen, Xiao-Fen, Zhang, Zhen-Lian, Wang, Zhe, Shi, Xin-Zhen, Xu, Kai, Zhang, Yun-Wu, Xu, Huaxi, Bu, Guojun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Alzheimer disease Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals cytokine DAP12 HEK293 Cells Humans inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - metabolism Inflammation - pathology lipopolysaccharide (LPS) Lipopolysaccharides - toxicity Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice microglia Mutation Neurobiology Protein Stability - drug effects Protein Structure, Tertiary Receptors, Immunologic - genetics Receptors, Immunologic - metabolism TREM-CTF TREM2 γ-secretase
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