Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma
AIM: To investigate expression and significance of inhibitor ofapoptosis protein survivin in hepatocellular cardnoma (HCC). METHODS: The expression of survivin and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC tissues and 38 liver cirrhosis tissues by immunohistochemi...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-07, Vol.11 (25), p.3855-3859 |
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| creator | Zhu, Hong Chen, Xiao-Ping Zhang, Wan-Guang Luo, Shun-Feng Zhang, Bi-Xiang |
| description | AIM: To investigate expression and significance of inhibitor ofapoptosis protein survivin in hepatocellular cardnoma (HCC). METHODS: The expression of survivin and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC tissues and 38 liver cirrhosis tissues by immunohistochemistry and Western blot, The relationship between the expression of survivin and clinicopathological factors of HCC was analyzed, RESULTS: Survivin protein was detected in 23 (60.5%) of 38 HCCs and 3 (7.9%) of 38 liver cirrhosis tissues. In 23 cases of HCC which expressed survivin, the expression of VEGF was positive in 18 cases and slight positive or negative in 5 cases. While in 15 cases of HCC which did not express survivin, 12 cases did not express or slightly expressed, and 3 cases expressed VEGF. In liver cirrhosis tissues, the expression of VEGF was as follows: 24 cases were negative, 10 cases were weak positive and 4 cases were strong positive. The expression of survivin was coincident with the expression of VEGF in HCC (P |
| doi_str_mv | 10.3748/wjg.v11.i25.3855 |
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| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4504885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>16078120</cqvip_id><wanfj_id>wjg200525009</wanfj_id><sourcerecordid>wjg200525009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-a49ff5c81f9756505ebe3a10e9572e72c2fc85b932c48f8f5daee82987b022a93</originalsourceid><addsrcrecordid>eNpVUU2LFDEQDaK4s6t3T9KIeOsxH51J-iLIsq7Cghc9h-pMpSdjT9KbdM_ovzfNDH5AIKHy6tV79Qh5xehaqEa_P-379ZGxtedyLbSUT8iKc9bWXDf0KVkxSlXdCq6uyHXOe0q5EJI_J1dMti3jmq-Iu_s5JszZx1BB2FbZ98E7byFYrKKrAp4qH3a-81NMSwHGOE4x-1yNKU7oQ5XndPTH8ihnhyNM0eIwzAOkykKyPsQDvCDPHAwZX17uG_L9092328_1w9f7L7cfH2rbSDrV0LTOSauZa5XcSCqxQwGMYisVR8Utd1bLrliyjXbayS0gat5q1VHOoRU35MOZd5y7A24thinBYMbkD5B-mQje_P8T_M708WjK-EZrWQjenglOEByE3uzjnEKRbMquOaWSS0qXOe8uc1J8nDFP5uDzYhsCxjmbjVoWLFgB0jPQpphzQvdHC6NmyXDhNSVDUzI0S4al5fW_Hv42XEIrgDcXzl0M_aMvKjuwP5wf0LANVZpxKn4DchGndA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67991231</pqid></control><display><type>article</type><title>Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhu, Hong ; Chen, Xiao-Ping ; Zhang, Wan-Guang ; Luo, Shun-Feng ; Zhang, Bi-Xiang</creator><creatorcontrib>Zhu, Hong ; Chen, Xiao-Ping ; Zhang, Wan-Guang ; Luo, Shun-Feng ; Zhang, Bi-Xiang</creatorcontrib><description>AIM: To investigate expression and significance of inhibitor ofapoptosis protein survivin in hepatocellular cardnoma (HCC). METHODS: The expression of survivin and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC tissues and 38 liver cirrhosis tissues by immunohistochemistry and Western blot, The relationship between the expression of survivin and clinicopathological factors of HCC was analyzed, RESULTS: Survivin protein was detected in 23 (60.5%) of 38 HCCs and 3 (7.9%) of 38 liver cirrhosis tissues. In 23 cases of HCC which expressed survivin, the expression of VEGF was positive in 18 cases and slight positive or negative in 5 cases. While in 15 cases of HCC which did not express survivin, 12 cases did not express or slightly expressed, and 3 cases expressed VEGF. In liver cirrhosis tissues, the expression of VEGF was as follows: 24 cases were negative, 10 cases were weak positive and 4 cases were strong positive. The expression of survivin was coincident with the expression of VEGF in HCC (P<0.01). The expression of survivin in HCC had no relationship with the patients'age, gender, tumor size and differentiation level of HCC, while it was related to the metastasis of HCC. The protein quantitative analysis by Western blot also showed that overexpression of survivin in HCC was closely correlated to the expression of VEGF (P<0.01). Furthermore, stronger expression of survivin and VEGF was also found in patients with metastasis rather than in those with no metastasis (P<0.01). CONCLUSION: Survivin plays a pivotal role in the metastasis of HCC, and it has some correlation with tumorigenesis. The expression of survivin in the primary lesion is very useful as an indicator for metastasis and prognosis of HCC. It could become a new target of gene therapy of HCC.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i25.3855</identifier><identifier>PMID: 15991282</identifier><language>eng</language><publisher>United States: Hepatic Surgery Center, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China</publisher><subject>Adult ; Aged ; Antigens, Neoplasm - metabolism ; Apoptosis ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - physiopathology ; Female ; Humans ; Inhibitor of Apoptosis Proteins ; Liver Cancer ; Liver Neoplasms - metabolism ; Liver Neoplasms - physiopathology ; Male ; Microtubule-Associated Proteins - metabolism ; Middle Aged ; Neoplasm Proteins - metabolism ; Survivin ; 凋亡蛋白 ; 基因表达 ; 抑制剂 ; 肝细胞癌</subject><ispartof>World journal of gastroenterology : WJG, 2005-07, Vol.11 (25), p.3855-3859</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-a49ff5c81f9756505ebe3a10e9572e72c2fc85b932c48f8f5daee82987b022a93</citedby><cites>FETCH-LOGICAL-c450t-a49ff5c81f9756505ebe3a10e9572e72c2fc85b932c48f8f5daee82987b022a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504885/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504885/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15991282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Hong</creatorcontrib><creatorcontrib>Chen, Xiao-Ping</creatorcontrib><creatorcontrib>Zhang, Wan-Guang</creatorcontrib><creatorcontrib>Luo, Shun-Feng</creatorcontrib><creatorcontrib>Zhang, Bi-Xiang</creatorcontrib><title>Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To investigate expression and significance of inhibitor ofapoptosis protein survivin in hepatocellular cardnoma (HCC). METHODS: The expression of survivin and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC tissues and 38 liver cirrhosis tissues by immunohistochemistry and Western blot, The relationship between the expression of survivin and clinicopathological factors of HCC was analyzed, RESULTS: Survivin protein was detected in 23 (60.5%) of 38 HCCs and 3 (7.9%) of 38 liver cirrhosis tissues. In 23 cases of HCC which expressed survivin, the expression of VEGF was positive in 18 cases and slight positive or negative in 5 cases. While in 15 cases of HCC which did not express survivin, 12 cases did not express or slightly expressed, and 3 cases expressed VEGF. In liver cirrhosis tissues, the expression of VEGF was as follows: 24 cases were negative, 10 cases were weak positive and 4 cases were strong positive. The expression of survivin was coincident with the expression of VEGF in HCC (P<0.01). The expression of survivin in HCC had no relationship with the patients'age, gender, tumor size and differentiation level of HCC, while it was related to the metastasis of HCC. The protein quantitative analysis by Western blot also showed that overexpression of survivin in HCC was closely correlated to the expression of VEGF (P<0.01). Furthermore, stronger expression of survivin and VEGF was also found in patients with metastasis rather than in those with no metastasis (P<0.01). CONCLUSION: Survivin plays a pivotal role in the metastasis of HCC, and it has some correlation with tumorigenesis. The expression of survivin in the primary lesion is very useful as an indicator for metastasis and prognosis of HCC. It could become a new target of gene therapy of HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm - metabolism</subject><subject>Apoptosis</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Liver Cancer</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - physiopathology</subject><subject>Male</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Survivin</subject><subject>凋亡蛋白</subject><subject>基因表达</subject><subject>抑制剂</subject><subject>肝细胞癌</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU2LFDEQDaK4s6t3T9KIeOsxH51J-iLIsq7Cghc9h-pMpSdjT9KbdM_ovzfNDH5AIKHy6tV79Qh5xehaqEa_P-379ZGxtedyLbSUT8iKc9bWXDf0KVkxSlXdCq6uyHXOe0q5EJI_J1dMti3jmq-Iu_s5JszZx1BB2FbZ98E7byFYrKKrAp4qH3a-81NMSwHGOE4x-1yNKU7oQ5XndPTH8ihnhyNM0eIwzAOkykKyPsQDvCDPHAwZX17uG_L9092328_1w9f7L7cfH2rbSDrV0LTOSauZa5XcSCqxQwGMYisVR8Utd1bLrliyjXbayS0gat5q1VHOoRU35MOZd5y7A24thinBYMbkD5B-mQje_P8T_M708WjK-EZrWQjenglOEByE3uzjnEKRbMquOaWSS0qXOe8uc1J8nDFP5uDzYhsCxjmbjVoWLFgB0jPQpphzQvdHC6NmyXDhNSVDUzI0S4al5fW_Hv42XEIrgDcXzl0M_aMvKjuwP5wf0LANVZpxKn4DchGndA</recordid><startdate>20050707</startdate><enddate>20050707</enddate><creator>Zhu, Hong</creator><creator>Chen, Xiao-Ping</creator><creator>Zhang, Wan-Guang</creator><creator>Luo, Shun-Feng</creator><creator>Zhang, Bi-Xiang</creator><general>Hepatic Surgery Center, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050707</creationdate><title>Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma</title><author>Zhu, Hong ; Chen, Xiao-Ping ; Zhang, Wan-Guang ; Luo, Shun-Feng ; Zhang, Bi-Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-a49ff5c81f9756505ebe3a10e9572e72c2fc85b932c48f8f5daee82987b022a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Neoplasm - metabolism</topic><topic>Apoptosis</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Inhibitor of Apoptosis Proteins</topic><topic>Liver Cancer</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - physiopathology</topic><topic>Male</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Survivin</topic><topic>凋亡蛋白</topic><topic>基因表达</topic><topic>抑制剂</topic><topic>肝细胞癌</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Hong</creatorcontrib><creatorcontrib>Chen, Xiao-Ping</creatorcontrib><creatorcontrib>Zhang, Wan-Guang</creatorcontrib><creatorcontrib>Luo, Shun-Feng</creatorcontrib><creatorcontrib>Zhang, Bi-Xiang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Hong</au><au>Chen, Xiao-Ping</au><au>Zhang, Wan-Guang</au><au>Luo, Shun-Feng</au><au>Zhang, Bi-Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2005-07-07</date><risdate>2005</risdate><volume>11</volume><issue>25</issue><spage>3855</spage><epage>3859</epage><pages>3855-3859</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To investigate expression and significance of inhibitor ofapoptosis protein survivin in hepatocellular cardnoma (HCC). METHODS: The expression of survivin and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC tissues and 38 liver cirrhosis tissues by immunohistochemistry and Western blot, The relationship between the expression of survivin and clinicopathological factors of HCC was analyzed, RESULTS: Survivin protein was detected in 23 (60.5%) of 38 HCCs and 3 (7.9%) of 38 liver cirrhosis tissues. In 23 cases of HCC which expressed survivin, the expression of VEGF was positive in 18 cases and slight positive or negative in 5 cases. While in 15 cases of HCC which did not express survivin, 12 cases did not express or slightly expressed, and 3 cases expressed VEGF. In liver cirrhosis tissues, the expression of VEGF was as follows: 24 cases were negative, 10 cases were weak positive and 4 cases were strong positive. The expression of survivin was coincident with the expression of VEGF in HCC (P<0.01). The expression of survivin in HCC had no relationship with the patients'age, gender, tumor size and differentiation level of HCC, while it was related to the metastasis of HCC. The protein quantitative analysis by Western blot also showed that overexpression of survivin in HCC was closely correlated to the expression of VEGF (P<0.01). Furthermore, stronger expression of survivin and VEGF was also found in patients with metastasis rather than in those with no metastasis (P<0.01). CONCLUSION: Survivin plays a pivotal role in the metastasis of HCC, and it has some correlation with tumorigenesis. The expression of survivin in the primary lesion is very useful as an indicator for metastasis and prognosis of HCC. It could become a new target of gene therapy of HCC.</abstract><cop>United States</cop><pub>Hepatic Surgery Center, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China</pub><pmid>15991282</pmid><doi>10.3748/wjg.v11.i25.3855</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antigens, Neoplasm - metabolism Apoptosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - physiopathology Female Humans Inhibitor of Apoptosis Proteins Liver Cancer Liver Neoplasms - metabolism Liver Neoplasms - physiopathology Male Microtubule-Associated Proteins - metabolism Middle Aged Neoplasm Proteins - metabolism Survivin 凋亡蛋白 基因表达 抑制剂 肝细胞癌 |
| title | Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma |
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