Colocalization of aromatase in spinal cord astrocytes: Differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor

Highlights • Tumor nociception is associated with increases in spinal astrocyte activity. • Tumor nociception is associated with increases in spinal aromatase expression. • Administration of an aromatase inhibitor reduces tumor-induced hyperalgesia.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-08, Vol.301, p.235-245
Hauptverfasser:	O’Brien, E.E, Smeester, B.A, Michlitsch, K.S, Lee, J-H, Beitz, A.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antineoplastic Agents - therapeutic use aromatase Aromatase - metabolism astrocytes Bone Neoplasms - complications Bone Neoplasms - drug therapy Bone Neoplasms - pathology cancer pain Cell Line, Tumor Disease Models, Animal Fibrosarcoma - complications Fibrosarcoma - drug therapy Fibrosarcoma - pathology Gene Expression Regulation, Neoplastic - drug effects Glial Fibrillary Acidic Protein Hyperalgesia - etiology Hyperalgesia - pathology letrozole Male mechanical hyperalgesia Mice Mice, Inbred C3H Mice, Inbred C57BL Microglia - enzymology Nerve Tissue Proteins - metabolism Neurology Nitriles - therapeutic use Pain - complications Pain - etiology Pain Threshold spinal cord Spinal Cord - pathology Triazoles - therapeutic use
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Beschreibung
Zusammenfassung:	Highlights • Tumor nociception is associated with increases in spinal astrocyte activity. • Tumor nociception is associated with increases in spinal aromatase expression. • Administration of an aromatase inhibitor reduces tumor-induced hyperalgesia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.009