Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress
Patients with major depressive disorder have a higher prevalence and incidence of dyslipidemia. However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolis...
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| creator | Tang, Mimi Jiang, Pei Li, Huande Liu, Yiping Cai, Hualin Dang, Ruili Zhu, Wenye Cao, Lingjuan |
| description | Patients with major depressive disorder have a higher prevalence and incidence of dyslipidemia. However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolism. Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system. In the present study, we investigated lipid metabolism in rats exposed to chronic unpredictable mild stress (CUMS) and the effect of fish oil on lipid profiles, aforementioned adipokines and ghrelin.
Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.
After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.
Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously. |
| doi_str_mv | 10.1186/s12906-015-0778-1 |
| format | Article |
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Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.
After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.
Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/s12906-015-0778-1</identifier><identifier>PMID: 26183327</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>adiponectin ; Animals ; antidepressants ; Behavior, Animal - drug effects ; blood serum ; cholesterol ; complement ; Depression ; Dietary Supplements ; fish oils ; Fish Oils - administration & dosage ; Fish Oils - pharmacology ; free fatty acids ; ghrelin ; glucose ; Health aspects ; hyperlipidemia ; leptin ; lipid metabolism ; Lipid Metabolism - drug effects ; Lipids - blood ; Medical research ; Medicine, Experimental ; mental depression ; Rats ; Stress, Physiological - drug effects ; Stress, Psychological - metabolism ; sucrose ; triacylglycerols</subject><ispartof>BMC complementary and alternative medicine, 2015-07, Vol.15 (1), p.239-239, Article 239</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Tang et al. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-b1c0d3ed7d86e2f4b51e97273ec0b4003927b89802e939a5cc2dc13abf2fb6263</citedby><cites>FETCH-LOGICAL-c628t-b1c0d3ed7d86e2f4b51e97273ec0b4003927b89802e939a5cc2dc13abf2fb6263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504181/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504181/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26183327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Mimi</creatorcontrib><creatorcontrib>Jiang, Pei</creatorcontrib><creatorcontrib>Li, Huande</creatorcontrib><creatorcontrib>Liu, Yiping</creatorcontrib><creatorcontrib>Cai, Hualin</creatorcontrib><creatorcontrib>Dang, Ruili</creatorcontrib><creatorcontrib>Zhu, Wenye</creatorcontrib><creatorcontrib>Cao, Lingjuan</creatorcontrib><title>Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Patients with major depressive disorder have a higher prevalence and incidence of dyslipidemia. However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolism. Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system. In the present study, we investigated lipid metabolism in rats exposed to chronic unpredictable mild stress (CUMS) and the effect of fish oil on lipid profiles, aforementioned adipokines and ghrelin.
Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.
After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.
Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.</description><subject>adiponectin</subject><subject>Animals</subject><subject>antidepressants</subject><subject>Behavior, Animal - drug effects</subject><subject>blood serum</subject><subject>cholesterol</subject><subject>complement</subject><subject>Depression</subject><subject>Dietary Supplements</subject><subject>fish oils</subject><subject>Fish Oils - administration & dosage</subject><subject>Fish Oils - pharmacology</subject><subject>free fatty acids</subject><subject>ghrelin</subject><subject>glucose</subject><subject>Health aspects</subject><subject>hyperlipidemia</subject><subject>leptin</subject><subject>lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids - blood</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>mental depression</subject><subject>Rats</subject><subject>Stress, Physiological - drug effects</subject><subject>Stress, Psychological - metabolism</subject><subject>sucrose</subject><subject>triacylglycerols</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkt9r1TAUx4sobk7_AF8kIMheOnOS3jZ9EcbYVBj4os8hTU7XzDSpSXuZf4X_sql3zntFkEB-kM_5npOTb1G8BHoGIOq3CVhL65LCpqRNI0p4VBxD1bCyFoI93tsfFc9SuqUUGgHV0-KI1SA4Z81x8ePKpoEE60hapsnhiH5Wsw2eKOdwa9WMiRicIqak_Fw6-xVJh4Pa2hATUd6QMZjF_eKcnawhUwy9dfloPYlqTgTvppDQkDkQPcTgrSaLz4rG6ll1DslonSFpXnM8L570yiV8cb-eFF-uLj9ffCivP73_eHF-XeqaibnsQFPD0TRG1Mj6qtsAtg1rOGraVZTyljWdaAVl2PJWbbRmRgNXXc_6rmY1Pyne7XSnpRvR6PzsqJycoh1V_C6DsvLwxttB3oStrDa0AgFZ4PReIIZvC6ZZjjZpdE55DEuSrGEcAFrO_4tCnUsH3lYso6__Qm_DEn3uhMx_R5s88foPdaMcSuv7kEvUq6g831RQVZRXa9qzf1B5GBytDh7XXzoMeLMXMKBy85CCW1Y7pEMQdqCOIaWI_UPfgMrVmXLnTJmdKVdnyrVfr_Yb_hDx24r8J0LY4CM</recordid><startdate>20150717</startdate><enddate>20150717</enddate><creator>Tang, Mimi</creator><creator>Jiang, Pei</creator><creator>Li, Huande</creator><creator>Liu, Yiping</creator><creator>Cai, Hualin</creator><creator>Dang, Ruili</creator><creator>Zhu, Wenye</creator><creator>Cao, Lingjuan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20150717</creationdate><title>Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress</title><author>Tang, Mimi ; 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However, clinical studies concerning the association between lipid levels and depression are inconsistent. Adipokines (like leptin and adiponectin) and ghrelin are strongly associated with lipid metabolism. Fish oil, which is reported to possess antidepressant effect, also have beneficial effects on lipid metabolism and the cardiovascular system. In the present study, we investigated lipid metabolism in rats exposed to chronic unpredictable mild stress (CUMS) and the effect of fish oil on lipid profiles, aforementioned adipokines and ghrelin.
Sucrose preference test (SPT), open field test (OFT) and forced swimming test (FST) were used to evaluate the antidepressant-like effects of fish oil. After the behavior tests, peripheral blood were collected. Serum parameters, including fasting triglyceride (TG), total cholesterol (TCH), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), free fatty acid (FFA), glucose (GLU), adipokines (leptin, adiponectin) and ghrelin were assayed.
After 5 weeks of CUMS procedures, rats were induced to depressive-like state, and exhibited increased serum levels of TCH, HDL-c, FFA and decreased serum levels of leptin and ghrelin, whereas the serum status of adiponectin, GLU, TG and LDL-c remained stable. Fish oil treatment showed robust antidepressant effect and reversed the stress-induced lipid disturbance and decrease in serum concentration of ghrelin.
Our results suggested that CUMS altered the serum levels of lipid profiles, leptin and ghrelin in rats. Fish oil supplementation not only provided antidepressant-like effects, but also reversed the altered lipid profiles and ghrelin level in serum. Our data indicated that fish oil treatment exerts anti-depressant effect and regulates lipid disturbance simultaneously.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26183327</pmid><doi>10.1186/s12906-015-0778-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adiponectin Animals antidepressants Behavior, Animal - drug effects blood serum cholesterol complement Depression Dietary Supplements fish oils Fish Oils - administration & dosage Fish Oils - pharmacology free fatty acids ghrelin glucose Health aspects hyperlipidemia leptin lipid metabolism Lipid Metabolism - drug effects Lipids - blood Medical research Medicine, Experimental mental depression Rats Stress, Physiological - drug effects Stress, Psychological - metabolism sucrose triacylglycerols |
| title | Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress |
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