P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

•P2X7R-driven IL-1 responses are markedly enhanced in BMDC compared to BMM.•P2X7R antagonist A-740003 inhibitedIL-1 release in BMDC and BMM.•P2X7R-induced pore formation was greater in BMDC than in BMM.•LPS-primed BMDC resisted ATP-induced cell death in comparison to BMM. The P2X7R is a functionally...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2015-08, Vol.74 (2), p.293-304
Hauptverfasser:	Englezou, Pavlos C., Rothwell, Simon W., Ainscough, Joseph S., Brough, David, Landsiedel, Robert, Verkhratsky, Alexei, Kimber, Ian, Dearman, Rebecca J.
Format:	Artikel
Sprache:	eng
Schlagworte:	A-740003 Animals Bone Marrow Cells - cytology Bone Marrow Cells - immunology Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Female Interleukin-1 Interleukin-1alpha - immunology Interleukin-1beta - immunology Macrophages Macrophages - cytology Macrophages - immunology Mice Mice, Inbred BALB C P2X7R Receptors, Purinergic P2X7 - immunology
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