Genetic stability of pneumococcal isolates during 35 days of human experimental carriage

Highlights • The experimental human carriage (EHPC) inoculum is genetically stable over 35 days. • Documentation of stability further addresses concerns of validity and safety of EHPC. • Confidence in EHPC to safely and reproducibly measure VEcol is key to aiding vaccine licensure.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-06, Vol.33 (29), p.3342-3345
Hauptverfasser:	Gladstone, R.A, Gritzfeld, J.F, Coupland, P, Gordon, S.B, Bentley, S.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergy and Immunology Carrier State - microbiology Conflicts of interest DNA, Bacterial - chemistry DNA, Bacterial - genetics Experimental human pneumococcal carriage Genetic Variation Genomes Genotype Healthy Volunteers Hospitals Humans Immunization Inoculum Middle Aged Pneumococcal Infections - microbiology Pneumococcal vaccines Pneumonia Polymorphism, Single Nucleotide Sequence Analysis, DNA Single-nucleotide polymorphism Stability Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Vaccine efficacy Vaccine efficacy against carriage (VEcol) Vaccines Variation Volunteers Young Adult
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Beschreibung
Zusammenfassung:	Highlights • The experimental human carriage (EHPC) inoculum is genetically stable over 35 days. • Documentation of stability further addresses concerns of validity and safety of EHPC. • Confidence in EHPC to safely and reproducibly measure VEcol is key to aiding vaccine licensure.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.05.021