Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back

Molecular dynamics simulations of smooth and striated muscle myosin regulatory light chain (RLC) N-terminal extension (NTE) showed that diphosphorylation induces a disorder-to-order transition. Our goal here was to further explore the effects of mono- and diphosphorylation on the straightening and r...

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Veröffentlicht in:	Molecular bioSystems 2015-08, Vol.11 (8), p.2180-2189
Hauptverfasser:	Alamo, Lorenzo, Li, Xiaochuan Edward, Espinoza-Fonseca, L Michel, Pinto, Antonio, Thomas, David D, Lehman, William, Padrón, Raúl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachnida - chemistry Arachnida - metabolism Calcium - metabolism Molecular Dynamics Simulation Muscle, Smooth - chemistry Muscle, Smooth - metabolism Myosin Light Chains - chemistry Myosin Light Chains - metabolism Phosphorylation Protein Folding Protein Structure, Secondary
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