HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma

Summary Heat shock proteins (HSPs) are a super family of highly conserved molecular chaperone proteins, which are induced in response to stress. HSP70 has been demonstrated to inhibit apoptosis induced by a number of chemotherapeutic agents. Previous investigations have suggested the development of...

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Veröffentlicht in:	British journal of haematology 2008-08, Vol.142 (4), p.551-561
Hauptverfasser:	Nimmanapalli, Ramadevi, Gerbino, Elvira, Dalton, William S., Gandhi, Varsha, Alsina, Melissa
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Antineoplastic Agents, Alkylating - pharmacology Apoptosis - drug effects Biological and medical sciences Cell Adhesion cell adhesion mediated resistance Cell Death - drug effects Cell Line, Tumor drug resistance Drug Resistance, Neoplasm - physiology Fibronectins - metabolism Hematologic and hematopoietic diseases HSP70 HSP70 Heat-Shock Proteins - antagonists & inhibitors Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Melphalan - pharmacology multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Plasma Cells - drug effects Plasma Cells - metabolism
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