Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ)

Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. The activity of the enzyme is primarily regulated by a negative feedback mechanism involving ODC antizyme (AZ). Our previ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular signalling 2015-09, Vol.27 (9), p.1850-1859
Hauptverfasser:	Ray, Ramesh M., Bavaria, Mitul, Johnson, Leonard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Amino acids Animals Biogenic Polyamines - pharmacology Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Mice, Mutant Strains Mouse embryonic fibroblasts mTORC1/2 Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Ornithine decarboxylase p70S6 kinase Protein Biosynthesis - drug effects Protein Biosynthesis - genetics Proteins - genetics Proteins - metabolism Signal Transduction - drug effects Spermidine TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism TSC2 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!