Molecular heterogeneity of RET loss of function in Hirschsprung's disease

The RET proto‐oncogene encodes a receptor with tyrosine kinase activity (RET) that is involved in several neoplastic and non‐neoplastic diseases. Oncogenic activation of RET, achieved by different mechanisms, is detected in a sizeable fraction of human thyroid tumors, as well as in multiple endocrin...

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Veröffentlicht in:	The EMBO journal 1996-06, Vol.15 (11), p.2717-2725
Hauptverfasser:	Carlomagno, F., De Vita, G., Berlingieri, M. T., Franciscis, V., Melillo, R. M., Colantuoni, V., Kraus, M. H., Di Fiore, P. P., Fusco, A., Santoro, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Base Sequence DNA Primers - chemistry DNA-Binding Proteins - genetics Drosophila Proteins Early Growth Response Protein 1 Gene Expression Regulation, Neoplastic Hirschsprung Disease - genetics Humans Immediate-Early Proteins Mice Molecular Sequence Data Neuropeptides PC12 Cells Point Mutation Proteins - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Rats Receptor Protein-Tyrosine Kinases - genetics RNA, Messenger - genetics Structure-Activity Relationship Transcription Factors - genetics
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