Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain

Little is known about ageing-related changes in the brain that affect emergence from general anaesthesia. We used young adult and aged Fischer 344 rats to test the hypothesis that ageing delays emergence from general anaesthesia by increasing anaesthetic sensitivity in the brain. Time to emergence w...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2015-07, Vol.115 (suppl_1), p.i58-i65
Hauptverfasser:	Chemali, J.J., Kenny, J.D., Olutola, O., Taylor, N.E., Kimchi, E.Y., Purdon, P.L., Brown, E.N., Solt, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	ageing Aging - physiology Anesthesia, General Anesthetics - pharmacology Animals Brain - drug effects delayed emergence from anaesthesia electroencephalography Electroencephalography - drug effects Isoflurane - pharmacology Male Methylphenidate - pharmacology Original Propofol - pharmacology Rats Rats, Inbred F344
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