Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions

The ErbB family includes two receptors, ErbB‐1 and ErbB‐3, that respectively bind to epidermal growth factor and Neu differentiation factor, and an orphan receptor, ErbB‐2. Unlike ErbB‐1 and ErbB‐2, the intrinsic tyrosine kinase of ErbB‐3 is catalytically impaired. By using interleukin‐3‐dependent c...

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Veröffentlicht in:	The EMBO journal 1996-05, Vol.15 (10), p.2452-2467
Hauptverfasser:	Pinkas‐Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, I., Klapper, L., Lavi, S., Seger, R., Ratzkin, B. J., Sela, M., Yarden, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Line Epidermal Growth Factor - chemistry Epidermal Growth Factor - physiology Glycoproteins - physiology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Humans Interleukin-3 - pharmacology Mice Models, Biological Molecular Sequence Data Neuregulins Phosphorylation Protein Conformation Protein Kinases - metabolism Protein Multimerization Protein Processing, Post-Translational Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - physiology Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - physiology Receptor, ErbB-2 - physiology Receptor, ErbB-3 Recombinant Proteins - drug effects Recombinant Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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