Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry

Introduction The immunosuppressive enzyme, indoleamine 2,3 dioxygenase (IDO), is overexpressed in many different tumor types including breast cancer. IDO inhibitors synergize with chemotherapy in breast cancer murine models. Characterizing IDO expression in breast cancer could define which patients...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2013-05, Vol.62 (5), p.829-837
Hauptverfasser:	Soliman, Hatem, Rawal, Bhupendra, Fulp, Jimmy, Lee, Ji-Hyun, Lopez, Alexis, Bui, Marylin M., Khalil, Farah, Antonia, Scott, Yfantis, Harris G., Lee, Dong H., Dorsey, Tiffany H., Ambs, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - enzymology Cancer Research Cyclooxygenase 2 - metabolism Enzyme Inhibitors - pharmacology Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunohistochemistry - methods Immunology Immunotherapy Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Medical research Medicine Medicine & Public Health Models, Statistical Multivariate Analysis Oncology Original Article Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Regression Analysis Time Factors Treatment Outcome Tumors
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