Genetic and cellular dissection of the activation of AM14 rheumatoid factor B cells in a mouse model of lupus

Multiple genetic and cellular factors contribute to the activation of autoreactive B cells in the NZM2410 mouse model of lupus. The RF‐specific AM14 tg BCR has been used as a model to dissect the mechanisms of B cell tolerance to ICs containing nucleic acids. We have shown previously that AM14 RF B...

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Veröffentlicht in:	Journal of leukocyte biology 2015-08, Vol.98 (2), p.209-221
Hauptverfasser:	Sang, Allison, Zheng, Ying Yi, Choi, Seung‐Chul, Zeumer, Leilani, Morel, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoantibody autoimmunity B cell tolerance B-Lymphocytes - immunology B-Lymphocytes - pathology BCR transgenic mice Cell Development, Differentiation, & Trafficking Cell Lineage - immunology Chromatin - immunology Disease Models, Animal Gene Expression Regulation Genetic Loci Humans Immune Tolerance Immunoglobulin G - genetics Immunoglobulin G - immunology Immunophenotyping Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymphocyte Activation Mice Mice, Transgenic Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Rheumatoid Factor - genetics Rheumatoid Factor - immunology Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - pathology Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology
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