Apolipoprotein A-IV inhibits experimental colitis

The antiatherogenic properties of apoA-IV suggest that this protein may act as an anti-inflammatory agent. We examined this possibility in a mouse model of acute colitis. Mice consumed 3% dextran sulfate sodium (DSS) in their drinking water for 7 days, with or without daily intraperitoneal injection...

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Veröffentlicht in:	The Journal of clinical investigation 2004-07, Vol.114 (2), p.260-269
Hauptverfasser:	Vowinkel, Thorsten, Mori, Mikiji, Krieglstein, Christian F, Russell, Janice, Saijo, Fumito, Bharwani, Sulaiman, Turnage, Richard H, Davidson, W Sean, Tso, Patrick, Granger, D Neil, Kalogeris, Theodore J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Antioxidants Apolipoproteins A - genetics Apolipoproteins A - immunology Apolipoproteins A - metabolism Atherosclerosis Biomedical research Colitis - chemically induced Colitis - immunology Colitis - metabolism Colitis - pathology Colon Colon - anatomy & histology Colon - pathology Dextran Sulfate - administration & dosage Dextran Sulfate - toxicity Diarrhea Disease Disease Models, Animal Epithelial Cells - cytology Epithelial Cells - metabolism Histology Humans Hypotheses Indicators and Reagents - administration & dosage Indicators and Reagents - toxicity Inflammation Inflammation - immunology Inflammation - metabolism Inflammatory bowel disease Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Leukocytes Leukocytes - immunology Leukocytes - metabolism Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout P-Selectin - metabolism Platelet Adhesiveness - physiology Proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism
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