Imaging pulmonary inducible nitric oxide synthase expression with PET

Inducible nitric oxide synthase (iNOS) activity increases in acute and chronic inflammatory lung diseases. Imaging iNOS expression may be useful as an inflammation biomarker for monitoring lung disease activity. We developed a novel tracer for PET that binds to iNOS in vivo, (18)F-NOS. In this study...

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Veröffentlicht in:	Journal of Nuclear Medicine 2015-01, Vol.56 (1), p.76-81
Hauptverfasser:	Huang, Howard J, Isakow, Warren, Byers, Derek E, Engle, Jacquelyn T, Griffin, Elizabeth A, Kemp, Debra, Brody, Steven L, Gropler, Robert J, Miller, J Philip, Chu, Wenhua, Zhou, Dong, Pierce, Richard A, Castro, Mario, Mach, Robert H, Chen, Delphine L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological Transport - drug effects Biomarkers Bronchoalveolar Lavage Cells Endotoxins - toxicity Female Gene Expression Regulation, Enzymologic - drug effects Healthy Volunteers Humans Immunohistochemistry Lung - diagnostic imaging Lung - drug effects Lung - enzymology Lung - metabolism Lung diseases Male Metabolites Nitric oxide Nitric Oxide Synthase Type II - metabolism Nuclear medicine Positron-Emission Tomography Radiopharmaceuticals - blood Radiopharmaceuticals - metabolism
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