Daily heat stress treatment rescues denervation‐activated mitochondrial clearance and atrophy in skeletal muscle

Key points Traumatic nerve injury or nerve disease leads to denervation and severe muscle atrophy. Recent evidence shows that mitochondrial loss could be a key mediator of skeletal muscle atrophy. Here, we show that daily heat stress treatment rescues denervation‐induced loss of mitochondria and con...

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Veröffentlicht in:	The Journal of physiology 2015-06, Vol.593 (12), p.2707-2720
Hauptverfasser:	Tamura, Yuki, Kitaoka, Yu, Matsunaga, Yutaka, Hoshino, Daisuke, Hatta, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Hot Temperature Male Mice, Inbred ICR Mitochondria - physiology Muscle Muscle Denervation Muscle, Skeletal - innervation Muscle, Skeletal - pathology Muscle, Skeletal - physiology Muscular Atrophy - physiopathology Oxidative Stress Sciatic Nerve - surgery
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