Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae

Nitroreductases are flavoenzymes that catalyze nitrocompounds and are widely utilized in industrial applications due to their detoxification potential and activation of biomedicinal prodrugs. Type I nitroreductases are classified into subgroups depending on the use of NADPH or NADH as the electron d...

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Veröffentlicht in:	Protein science 2015-07, Vol.24 (7), p.1158-1163
Hauptverfasser:	Song, Hyung‐Nam, Jeong, Dae‐Gwin, Bang, Seo‐Young, Paek, Se‐Hwan, Park, Byoung‐Chul, Park, Sung‐Goo, Woo, Eui‐Jeon
Format:	Artikel
Sprache:	eng
Schlagworte:	4‐nitroquinoline 1‐oxide Binding sites Chemical compounds Crystal structure Crystallography, X-Ray Detoxification Drugs Fungi Homology Industrial applications Models, Molecular NAD NADH NADP Nicotinamide adenine dinucleotide Nitroreductase Nitroreductases - chemistry Prodrugs Protein Conformation Protein Structure Reports Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae Proteins - chemistry Subgroups Substrates Yeast
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