Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Genetic factors are important determinants of the onset and progression of diabetes mellitus. Numerous susceptibility genes for type 2 diabetes, including potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1), have been identified in humans by genome-wide analyses and other studies....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-07, Vol.112 (27), p.8332-8337
Hauptverfasser:	Asahara, Shun-ichiro, Etoh, Hiroaki, Inoue, Hiroyuki, Teruyama, Kyoko, Shibutani, Yuki, Ihara, Yuka, Kawada, Yukina, Bartolome, Alberto, Hashimoto, Naoko, Matsuda, Tomokazu, Koyanagi-Kimura, Maki, Kanno, Ayumi, Hirota, Yushi, Hosooka, Tetsuya, Nagashima, Kazuaki, Nishimura, Wataru, Inoue, Hiroshi, Matsumoto, Michihiro, Higgins, Michael J, Yasuda, Kazuki, Inagaki, Nobuya, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological Sciences cell cycle cyclin-dependent kinase Cyclin-Dependent Kinase Inhibitor p57 - genetics Cyclin-Dependent Kinase Inhibitor p57 - metabolism Epigenesis, Genetic Gene Expression genomic imprinting Genomic Imprinting - genetics Glucose - pharmacology Glucose Tolerance Test histones humans Immunoblotting Inheritance Patterns Insulin - blood Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism islets of Langerhans KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism loci Male mice Mice, Knockout Mutation non-coding RNA noninsulin-dependent diabetes mellitus pathogenesis potassium promoter regions Reverse Transcriptase Polymerase Chain Reaction transgenic animals
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