Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane

Chlamydia trachomatis acquires C6‐NBD‐sphingomyelin endogenously synthesized from C6‐NBD‐ceramide and transported to the vesicle (inclusion) in which they multiply. Here we explore the mechanisms of this unusual trafficking and further characterize the association of the chlamydial inclusion with th...

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Veröffentlicht in:	The EMBO journal 1996-03, Vol.15 (5), p.964-977
Hauptverfasser:	Hackstadt, T., Rockey, D. D., Heinzen, R. A., Scidmore, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism Animals Anti-Bacterial Agents - pharmacology Biological Transport, Active Brefeldin A Cell Membrane - metabolism Ceramides - metabolism Chlamydia Infections - metabolism Chlamydia Infections - microbiology Chlamydia Infections - pathology Chlamydia trachomatis Chlamydia trachomatis - drug effects Chlamydia trachomatis - pathogenicity Chlamydia trachomatis - physiology Cyclopentanes - pharmacology Exocytosis Fluorescent Dyes - metabolism Golgi Apparatus - metabolism HeLa Cells Humans Inclusion Bodies - drug effects Inclusion Bodies - metabolism Inclusion Bodies - microbiology Macrolides Membrane Fusion Microscopy, Electron Models, Biological Sphingomyelins - metabolism
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