Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells

Tyrosine kinase inhibitors (TKIs) are mostly used in non-small cell lung cancer (NSCLC) treatment. Unfortunately, treatment with Gefitinib for a period of time will result in drug resistance and cause treatment failure in clinic. Therefore, exploring novel compounds to overcome this resistance is ur...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.8477, Article 8477
Hauptverfasser:	Cao, Wei, Liu, Ying, Zhang, Ran, Zhang, Bo, Wang, Teng, Zhu, Xianbing, Mei, Lin, Chen, Hongbo, Zhang, Hongling, Ming, Pinghong, Huang, Laiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 631/154/349 631/67/1612/1350 64/60 82/29 82/51 96/2 96/95 Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Antitumor activity Apoptosis Apoptosis - drug effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Survival - drug effects Drug resistance Drug Resistance, Neoplasm - drug effects Drug Synergism Enzyme-Linked Immunosorbent Assay Epidermal growth factor receptors Gefitinib Glycoprotein gp130 Harringtonines - chemistry Harringtonines - therapeutic use Harringtonines - toxicity Humanities and Social Sciences Humans Interleukin 6 Interleukin-6 - analysis Interleukin-6 - metabolism Janus kinase Janus Kinase 1 - metabolism Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Mice, Nude Mitochondria Mitochondria - drug effects Mitochondria - metabolism multidisciplinary Non-small cell lung carcinoma Phosphorylation Phosphorylation - drug effects Protein-tyrosine kinase Quinazolines - toxicity Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Science Signal Transduction - drug effects Stat3 protein STAT3 Transcription Factor - metabolism Taxoids - therapeutic use Taxoids - toxicity Transplantation, Heterologous Xenografts
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