Cellular Basis of Secondary Infections and Impaired Desquamation in Certain Inherited Ichthyoses

IMPORTANCE: Secondary infections and impaired desquamation complicate certain inherited ichthyoses, but their cellular basis remains unknown. In healthy human epidermis, the antimicrobial peptides cathelicidin (LL-37) and human β-defensin 2 (HBD2), as well as the desquamatory protease kallikrein-rel...

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Veröffentlicht in:	JAMA dermatology (Chicago, Ill.) Ill.), 2015-03, Vol.151 (3), p.285-292
Hauptverfasser:	Chan, Aegean, Godoy-Gijon, Elena, Nuno-Gonzalez, Almudena, Crumrine, Debra, Hupe, Melanie, Choi, Eung-Ho, Gruber, Robert, Williams, Mary L, Choate, Keith, Fleckman, Philip H, Elias, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides - metabolism beta-Defensins - metabolism Case-Control Studies Exocytosis Humans Ichthyosis - complications Ichthyosis - genetics Ichthyosis - pathology Immunohistochemistry Kallikreins - metabolism Microscopy, Electron Skin - pathology Skin Diseases, Infectious - etiology Skin Diseases, Infectious - pathology
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