WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We have performed laser capture microdissection with R...

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Veröffentlicht in:	Carcinogenesis (New York) 2015-05, Vol.36 (5), p.598-606
Hauptverfasser:	Long, Apple, Giroux, Véronique, Whelan, Kelly A, Hamilton, Kathryn E, Tétreault, Marie-Pier, Tanaka, Koji, Lee, Ju-Seog, Klein-Szanto, Andres J, Nakagawa, Hiroshi, Rustgi, Anil K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell Differentiation Cell Movement Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagus - metabolism Flow Cytometry Fluorescent Antibody Technique Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Mice Mice, Inbred C57BL Original Manuscript Phenotype Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured Wnt Proteins - genetics Wnt Proteins - metabolism
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