In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K-AKT signaling and are frequently dysregulated in human cancer. Although PTEN has been extensively studied, little is known about the underlying mechanisms by which INPP4B exerts its tumor-suppressive...

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Veröffentlicht in:	Cancer discovery 2015-07, Vol.5 (7), p.740-751
Hauptverfasser:	Li Chew, Chen, Lunardi, Andrea, Gulluni, Federico, Ruan, Daniel T, Chen, Ming, Salmena, Leonardo, Nishino, Michiya, Papa, Antonella, Ng, Christopher, Fung, Jacqueline, Clohessy, John G, Sasaki, Junko, Sasaki, Takehiko, Bronson, Roderick T, Hirsch, Emilio, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - genetics Adenocarcinoma, Follicular - pathology Animals Cell Line, Tumor Endosomes - metabolism Gene Expression Regulation, Neoplastic Gene Knockout Techniques Humans Mice Neoplasm Metastasis Phosphatidylinositol 3-Kinases - metabolism Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Signal Transduction Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology
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