Mast cells mediate malignant pleural effusion formation

Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine...

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Veröffentlicht in:	The Journal of clinical investigation 2015-06, Vol.125 (6), p.2317-2334
Hauptverfasser:	Giannou, Anastasios D, Marazioti, Antonia, Spella, Magda, Kanellakis, Nikolaos I, Apostolopoulou, Hara, Psallidas, Ioannis, Prijovich, Zeljko M, Vreka, Malamati, Zazara, Dimitra E, Lilis, Ioannis, Papaleonidopoulos, Vassilios, Kairi, Chrysoula A, Patmanidi, Alexandra L, Giopanou, Ioanna, Spiropoulou, Nikolitsa, Harokopos, Vaggelis, Aidinis, Vassilis, Spyratos, Dionisios, Teliousi, Stamatia, Papadaki, Helen, Taraviras, Stavros, Snyder, Linda A, Eickelberg, Oliver, Kardamakis, Dimitrios, Iwakura, Yoichiro, Feyerabend, Thorsten B, Rodewald, Hans-Reimer, Kalomenidis, Ioannis, Blackwell, Timothy S, Agalioti, Theodora, Stathopoulos, Georgios T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Benzamides - pharmacology Biomedical research Cancer Cancer therapies Care and treatment Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Flow cytometry Genetic aspects Humans Imatinib Mesylate Interleukin-1beta - genetics Interleukin-1beta - metabolism Lung Neoplasms - diet therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mast cells Mast Cells - metabolism Mast Cells - pathology Melanoma Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Mortality Physiological aspects Piperazines - pharmacology Pleural Cavity - metabolism Pleural Cavity - pathology Pleural effusion Pleural Effusion, Malignant - drug therapy Pleural Effusion, Malignant - genetics Pleural Effusion, Malignant - metabolism Pleural Effusion, Malignant - pathology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-kit - antagonists & inhibitors Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - pharmacology Rodents Studies Tryptases - genetics Tryptases - metabolism Tumors
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