Synthesis and bioactivity of nobilamide B

Synthesis and bioactivity of nobilamide B

An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. -Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was...

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Veröffentlicht in:RSC advances 2014, Vol.4 (71), p.37609-37612
Hauptverfasser: Jacinto, M P V, Flores, M S, Lin, Z, Concepcion, G P, Schmidt, E W, Faulkner, S, Villaraza, A J L
Format: Artikel
Sprache:eng
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Zusammenfassung:An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. -Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra06873d